Effects of carnitine to oxygen stress occurred in the reperfused myocardiumfrom the cyanotic congenital heart disease model

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We have created a rat model of cyanotic congenital heart disease by chronic hypoxic exposure. A constant Langendorff coronary perfusion system was adopted as a new model for examination of cardiac ischemic reperfusion injury. The result was that, contrary to expectations, the hearts from low oxygen exposed rats showed less suppression of cardiac function after ischemic reperfusion to the contrast with the control hearts. Currently, we are considering the sequential changes in the composition of membrane lipids, changes in lipid peroxide production, and changes in the concentration of antioxidant enzymes.