Gene expression of the secondary heart field cells of mouse model of congenital heart disease induced by maternal administration of retinoic acid
Gene expression of the secondary heart field cells of mouse model of congenital heart disease induced by maternal administration of retinoic acid
批准号:
21591406
负责人:
SHIRAISHI Isao
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Maternal administration of retinoic acid(E6.5-E9.5) induce wide spectrum of congenital heart anomalies including heterotaxy syndrome, situs inversus totalis, univentricular heart, common atrioventricular connection, hypoplastic left heart, persistent truncus arteriosus, aorto-pulmonary window, complete transposition of the great arteries, tetralogy of Fallot, interrupted aortic arch, which are similar to human congenital heart disease. We analyzed gene expression of the secondary heart field and the cardiac outflow tract of this mouse model by using DNA microarray. We found various sort of genes up-regulated and down-regulated at these areas.
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Heterotaxy Syndrome-from Molecular Mechanisms to Clinical Features and Managements
异位综合征——从分子机制到临床特征和治疗
DOI:
--
发表时间:
2012
期刊:
Circulation J
影响因子:
--
作者:
[Shiraishi I, Morishima M, Sanbe A, Ichikawa H]
通讯作者:
Ichikawa H
Current topics on cardiac embryology for congenital heart disease
先天性心脏病心脏胚胎学的当前主题
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shiraishi I, Morishima M, Sanbe A, Ichikawa H, 白石公, Shiraishi I]
通讯作者:
Shiraishi I
Maternal Administration of Retinoic Acid Induces Wide Variety of Complicated Congenital Heart Disease in Mice Embryos
母体给予视黄酸可在小鼠胚胎中诱发多种复杂的先天性心脏病
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Shiraishi I, Morishima M, Sanbe A, Ichikawa H, 白石公]
通讯作者:
白石公
「循環器病学-基礎と臨床-」第9章2:「先天性心疾患における発生異常、病態生理、診断および治療」
《心血管医学-基础与临床实践》第9章第2章:“先天性心脏病的发育异常、病理生理学、诊断和治疗”
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Shiraishi I, Morishima M, Sanbe A, Ichikawa H, 白石公, Shiraishi I, 白石公]
通讯作者:
白石公
Acute Rupture of Chordae Tendineae of the Mitral Valve in Infants -A Nationwide Survey in Japan Exploring a New Syndrome
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批准号:24591594
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2012
-
负责人:SHIRAISHI Isao
-
依托单位:
Gene analysis of mouse models of visceral heterotaxy syndrome and transposition of the great arteries induced by maternal administration of retinoic acids
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批准号:19591215
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:SHIRAISHI Isao
-
依托单位:
Cardioprotection with nuclear-targeted Akt/PKB
-
批准号:17591106
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2005
-
负责人:SHIRAISHI Isao
-
依托单位:
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes
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批准号:14570760
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:2002
-
负责人:SHIRAISHI Isao
-
依托单位:
Functional Analysis of small G protein during cardiac early morphogenesis
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批准号:12670769
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2000
-
负责人:SHIRAISHI Isao
-
依托单位:
Investigation of collagen type III knockout mouse
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批准号:10670748
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1998
-
负责人:SHIRAISHI Isao
-
依托单位:
海外基金