Pathophysilogy of psoriasis : analysis via SOCS1 KO mice in epidermis and T cell.

牛皮癣的病理生理学：通过 SOCS1 KO 小鼠的表皮和 T 细胞进行分析。

• 批准号: 21591433
• 负责人: HANAKAWA Yasushi
• 金额: $ 2.91万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591433/
• 关键词: 皮膚病理学; 乾癬; SOCS1; STAT; 表皮特異的; コンディショナルノックアウトマウス; K5-Cre

To investigate pathophysiology of chronic skin disease of psoriasis, the functional involvement of SOCS1 was analyzed. SOCS1 is the negative regulator of STATs, and epidermis-specific SOCS1 KO mice were investigated. KO mice showed delayed wound healing because of hyper-inflammation by cross talk between keratinocytes and immune cells.

为探讨银屑病慢性皮肤病的病理生理机制，分析SOCS1的功能参与。SOCS1是STAT的负调节因子，研究了表皮特异性SOCS1 KO小鼠。KO小鼠由于角质形成细胞和免疫细胞之间的串扰引起的过度炎症而显示出延迟的伤口愈合。

项目成果

Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice.

• DOI: 10.1371/journal.pone.0011275
• 发表时间: 2010-06-23
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Sayama K;Kajiya K;Sugawara K;Sato S;Hirakawa S;Shirakata Y;Hanakawa Y;Dai X;Ishimatsu-Tsuji Y;Metzger D;Chambon P;Akira S;Paus R;Kishimoto J;Hashimoto K
• 通讯作者: Hashimoto K

Delsyed wound healing in keratinocytes-specific conditional knockout mice of SOCS1

Delsyed 在角质形成细胞特异性条件性敲除 SOCS1 小鼠中的伤口愈合

• 发表时间: 2010
• 作者: 嶋岡弥生;籏持淳;濱崎洋一郎;山崎讐次;船越美由紀;管野美紀;大森浩志;Dai X;嶋岡弥生;籏持淳;籏持淳;Tohyama M;籏持淳;籏持淳;Hanakawa Y
• 通讯作者: Hanakawa Y

Nuclear translocation of Bcl3 and p50 triggers the expression of IL-22-inducible genes in keratinocytes of psoriasis

Bcl3 和 p50 的核易位触发银屑病角质形成细胞中 IL-22 诱导基因的表达

• 发表时间: 2011
• 作者: Tohyama M;et al
• 通讯作者: et al

E2 Polyubiquitin-conjugating Enzyme Ubc13 in Keratinocytes Is Essential for Epidermal Integrity

• DOI: 10.1074/jbc.m110.106484
• 发表时间: 2010-09-24
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Sayama, Koji;Yamamoto, Masahiro;Hashimoto, Koji
• 通讯作者: Hashimoto, Koji

Interactions between myofibroblast differentiation and epidermogenesis in constructing human living skin equivalents.

肌成纤维细胞分化和表皮发生在构建人类活体皮肤等效物中的相互作用。

• DOI: 10.1016/j.jdermsci.2011.10.008
• 发表时间: 2012
• 期刊: Journal of dermatological science
• 影响因子: 4.6
• 作者: Lujun Yang;K. Hashimoto;M. Tohyama;H. Okazaki;X. Dai;Y. Hanakawa;K. Sayama;Y. Shirakata
• 通讯作者: Y. Shirakata