Control of allergy with skin based immunomodulation

通过皮肤免疫调节控制过敏

• 批准号: 21591461
• 负责人: MIZUTANI Hitoshi
• 金额: $ 3.08万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591461/
• 关键词: アトピー性皮膚炎; Th2; ワクチン; サイトカイン; トランスジェニックマウス; IL-4; DNAワクチン; IL-13

Immunological balance in AD is shifted to Th2 dominant conditions, and we have been investigated various therapeutic method to correct Th2 shifted immune systems based on the skin immunomodulation systems. In addition to supplementation of exogenous immunomodulators to the skin, we have developed a skin specific dominant negative type mutant IL-4 expressing transgenic mouse. This mouse decreased inflammation in a hapteninduced experimental dermatitis at the early phase. Wild type mouse with skin graft from the transgenic mouse, also decreased inflammation and Th2 cytokine signal proteins mRNA expression in the skin lesions. This concept, production of therapeutic peptide from keratinocytes, is a potent therapeutic strategy for various systemic diseases including allergic diseases.

AD的免疫平衡向Th 2优势状态转移，我们已经研究了基于皮肤免疫调节系统的各种治疗方法来纠正Th 2转移的免疫系统。除了向皮肤补充外源性免疫调节剂之外，我们已经开发了皮肤特异性显性阴性型突变体IL-4表达转基因小鼠。这只小鼠在半抗原诱导的实验性皮炎的早期阶段减少了炎症。从转基因小鼠移植皮肤的野生型小鼠也降低了皮肤病变中的炎症和Th 2细胞因子信号蛋白mRNA表达。从角质形成细胞生产治疗肽的概念是治疗包括过敏性疾病在内的各种全身性疾病的有效治疗策略。

项目成果

遺伝子操作ADモデル:サイトカイントランスジェニックマウス

基因工程AD模型：细胞因子转基因小鼠

• 发表时间: 2011
• 期刊: 皮膚アレルギーフロンティア
• 作者: 山中恵一;水谷仁
• 通讯作者: 水谷仁

The Role of Cytokines/Chemokines in the Pathogenesis of Atopic Dermatitis

• DOI: 10.1159/000323299
• 发表时间: 2011-01-01
• 期刊: PATHOGENESIS AND MANAGEMENT OF ATOPIC DERMATITIS
• 作者: Yamanaka, Kei-ichi;Mizutani, Hitoshi
• 通讯作者: Mizutani, Hitoshi

アトピー性皮膚炎と自然免疫WHAT'S NEW IN皮膚科学2010-2011

特应性皮炎和先天免疫 2010-2011 年皮肤科新动态

• 发表时间: 2010
• 作者: Soo-Chan Kim;Won-Soo Lee. Kenzo Takahashi;水谷仁
• 通讯作者: 水谷仁

Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.

• DOI: 10.1371/journal.pone.0031465
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Tsuda K;Yamanaka K;Kitagawa H;Akeda T;Naka M;Niwa K;Nakanishi T;Kakeda M;Gabazza EC;Mizutani H
• 通讯作者: Mizutani H

SLIT Improves Cedar Pollinosis by Restoring IL-10 Production from Tr1 and Monocytes~IL-10 Productivity Is Critical for Becoming Allergic~.

• DOI: 10.2332/allergolint.10-oa-0198
• 发表时间: 2011
• 期刊: Allergology international : official journal of the Japanese Society of Allergology
• 作者: K. Yamanaka;A. Yuta;M. Kakeda;H. Kitagawa;Hitomi Ogihara;E. Gabazza;K. Okubo;I. Kurokawa;K. Takeuchi;H. Mizutani