Role of platelet in regulation of cutaneous inflammation

1)血小板在接触性超敏反应中的作用：通过给予抗血小板抗体或白消安，在有或没有血小板耗竭的情况下，用半抗原致敏并在耳中引发小鼠。在体显像显示，血小板被激活，与白细胞形成复合物，并在2 h内被吞噬到毛细血管中的白细胞的胞浆中。我们发现血小板在调节皮肤组织炎症反应的CD 11 r +Gr-1+白细胞的迁移中起重要作用。2）我们发现血小板在包括表皮朗格汉斯细胞在内的树突状细胞的再分布中起重要作用，这些树突状细胞可能在皮肤组织的致敏中起调节作用。我们表明血小板通过帮助具有调节功能的细胞迁移而在皮肤炎症中具有调节作用。

1) Role of platelets in contact hypersensitivity reaction : Mice were sensitized and elicited in ears with hapten, with or without platelet depletion, by administering antiplatelet antibody or busulfan. In vivo imaging demonstrated that platelets were activated, formed complex with leukocytes and engulfed into the cytoplasm of the leukocytes in the capillary within 2 hours after elicitation. We showed that platelets play important role in migration of CD11r+Gr-1+leukocytes which regulated inflammatory reaction in cutaneous tissue.2) We showed that platelets play important roles in redistribution of dendritic cells including epidermal Langerhans cells which may have regulatory function in sensitization to the skin tissue.Taken together, we show that platelets have regulatory roles in cutaneous inflammation by helping migration of cells with regulatory function.