Role of platelet in regulation of cutaneous inflammation

血小板在调节皮肤炎症中的作用

• 批准号: 21591472
• 负责人: KATOH Norito
• 金额: $ 2.91万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591472/
• 关键词: 皮膚炎症; 再生学; 血小板; 接触過敏反応; 炎症の収束; 樹状細胞; 白血球遊走; リンパ管; アトピー性皮膚炎; CD11b+Gr-1+細胞; 可視化

1) Role of platelets in contact hypersensitivity reaction : Mice were sensitized and elicited in ears with hapten, with or without platelet depletion, by administering antiplatelet antibody or busulfan. In vivo imaging demonstrated that platelets were activated, formed complex with leukocytes and engulfed into the cytoplasm of the leukocytes in the capillary within 2 hours after elicitation. We showed that platelets play important role in migration of CD11r+Gr-1+leukocytes which regulated inflammatory reaction in cutaneous tissue.2) We showed that platelets play important roles in redistribution of dendritic cells including epidermal Langerhans cells which may have regulatory function in sensitization to the skin tissue.Taken together, we show that platelets have regulatory roles in cutaneous inflammation by helping migration of cells with regulatory function.

1)血小板在接触性超敏反应中的作用：用半抗原致敏和诱导小鼠耳内注射抗血小板抗体或白消丹。活体成像显示，在激发后2小时内，血小板被激活，与白细胞形成复合体，并吞噬到毛细血管内白细胞的细胞质中。我们发现，血小板在调节皮肤组织炎症反应的CD11r+Gr-1+白细胞的迁移中起重要作用。2)我们发现，血小板在包括表皮朗格汉斯细胞在内的树突状细胞的再分布中发挥重要作用，可能对皮肤组织具有调节作用。

项目成果

Future perspectives in the treatment of atopic dermatitis.

特应性皮炎治疗的未来前景。

• 期刊: J Dermatol (印刷中)
• 作者: Inoue A;Tamagawa-Mineoka R;Katoh N;Kishimoto S;Katoh N.
• 通讯作者: Katoh N.

Platelet as versatile regulators of cutaneous inflammation

血小板作为皮肤炎症的多功能调节剂

• 发表时间: 2007
• 作者: Katoh N;Tamagawa-Mineoka R;Soga F;Kishimoto S.
• 通讯作者: Kishimoto S.

Persistent congenital milia involving the skin of the whole body in an infant with trisomy 13 syndrome.

13 三体综合征婴儿持续性先天性粟丘疹累及全身皮肤。

• 发表时间: 2010
• 期刊: Pediatr Dermatol (印刷中)
• 作者: Nakai N;Okuzawa Y;Katoh N;Kishimoto S.
• 通讯作者: Kishimoto S.

Anaphylaxis to vitamin B2 added to an energy drink.

对添加到能量饮料中的维生素 B2 产生过敏反应。

• 期刊: Clin Exp Dermatol (印刷中)
• 作者: Masuda K;Katoh N;Mizutani H;Kishimoto S.
• 通讯作者: Kishimoto S.

Immunohistological analysis of peptide-induced delayed-type hypersensitivity in advanced melanoma patients treated with melanoma antigen-pulsed mature monocyte-derived dendritic cell vaccination

• DOI: 10.1016/j.jdermsci.2008.07.013
• 发表时间: 2009-01-01
• 期刊: JOURNAL OF DERMATOLOGICAL SCIENCE
• 影响因子: 4.6
• 作者: Nakai, Noriaki;Katoh, Norito;Kishimoto, Saburo
• 通讯作者: Kishimoto, Saburo