Elucidation of schizophrenia etiology and development of a cure by the analysis of PSAT1 which is a gene relevant to serine synthesis.

点击翻译按钮获取中文摘要

In the schizophrenic patient, the enzyme activity of phosphoserine phospatase(PSP), which is one of L-serine synthetase, was increased as compared with the healthy comparisons. Plasma concentration of L-serine and the severity of illness were significantly related. Furthermore, the amount of mRNA of phosphoglycerate dehydrogenase(one of L-serine synthetase) was decreased and the amount of PSP was increased in schizophrenic patients compared with healthy comparisons. Therefore, abnormality of L-serine synthesis was found in schizophrenic patients.