Effect of cholinesterase inhibitor on symptoms and cerebral glucose metabolism in patients with dementia with Lewy bodies

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Cognitive function, neuropsychiatric symptoms, sleep disturbance, and cerebral glucose metabolism were evaluated in 9 patients with dementia with Lewy bodies before and after the administration of cholinesterase inhibitor(donepezil). Sleep disturbances were calculated from night-time activity, which was measured with a recording accelerometer called an ActiGraph. Cerebral glucose metabolism was measured with FDG-PET scan. Cognitive impairment, sleep disturbances, body movement during sleep, and hallucinations improved after donepezil treatment. Cerebral glucose metabolism in the right precuneus and posterior cingulated gyrus, and left middle frontal gyrus, orbitofrontal gyrus, precuneus, and cuneus improved after donepezil treatment.