Can inhaled oxygen be an MR contrast agent as a metabolic biosensor?

研究动脉血氧分压(PaO2)对磁共振T2*信号强度、r1和脑血流量(CBF)的影响，以了解吸入氧气能否作为MR对比剂作为代谢生物传感器。结果表明，通过测量动脉血和脑组织的纵向松弛时间的变化，可以无创地测量动脉血和脑组织氧分压的变化。此外，我们发现通过同时测量呼气末呼气末氧分压、脑血流量的变化和磁化率效应的变化来估计组织氧代谢量的可能性。

The effects of arterial pressure of oxygen(PaO2)on MRI T2* signal intensity, R1, and cerebral blood flow(CBF)were investigated to know if inhaled oxygen can be an MR contrast agent as a metabolic biosensor. The result showed that it is possible to measure changes in oxygen partial pressure of arterial blood and brain tissue noninvasively by measuring the change in longitudinal relaxation time. In addition, we found the possibility of estimating the amount of tissue oxygen metabolism by measuring simultaneously the end-tidal partial pressures of expired oxygen, the changes in the cerebral blood flow, and the changes in magnetic susceptibility effect.