assessment of central nervous system immunity in a rat glioma model by USPIO-enhanced magnetic resonance imaging

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Microglia has an important role in central nervous system immunity. Histopathologic studies of glioma tissue have revealed high levels of infiltrating microglia. Because microglia is an attractive candidate in immnotherapy for glioma, development of the method to monitor microglial function by magnetic resonance imaging is essential. We showed that ultra-small particles of iron oxide (USPIO) contrast agent could potentially enhance visualization of microglial function although the technique to suppress background signal intensity originating from USPIO outside of microglia should be needed.