Roles of irradiated stromal cells in the survival, growth, differentiation of sqamous cell carcinoma-derived cancer stem cells and its mechanisms研究代表者蒲地紀之(KAMOCHI NORIYUKI)

辐照基质细胞在鳞状细胞癌来源的癌症干细胞存活、生长、分化中的作用及其机制首席研究员 Kamochi NORIYUKI

• 批准号: 21591613
• 负责人: KAMOCHI Noriyuki
• 金额: $ 2.91万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591613/
• 关键词: 扁平上皮癌; 癌幹細胞; 線維芽細胞; 放射線; 増殖; 浸潤; 遺伝子不安定性

Non-irradiated fibroblasts promote the survival, self-renewal and cancer cell production of cancer stem cells under cancer stem cell-fibroblast interaction, while irradiated fibroblasts tend to promote those of the cancer stem cells. However, both fibroblast types show no significant difference between irradiated and non-irradiated fibroblasts. Finally, the irradiated fibroblasts-cancer stem cell interaction does not induce the significant change of the genomic instability marker p53-binding protein 1(53BP1) expression

在肿瘤干细胞-成纤维细胞相互作用下，未经辐射的成纤维细胞促进肿瘤干细胞的存活、自我更新和肿瘤细胞的产生，而经辐射的成纤维细胞倾向于促进肿瘤干细胞的存活、自我更新和肿瘤细胞的产生。然而，这两种类型的成纤维细胞在照射和未照射的成纤维细胞之间没有显著差异。最后，辐射后成纤维细胞与肿瘤干细胞的相互作用不会引起基因组不稳定标记P53结合蛋白1(53BP1)表达的显著变化

项目成果

A Promising Culture Model for Analyzing the Interaction between Adipose Tissue and Cardiomyocytes

• DOI: 10.1210/en.2010-1106
• 发表时间: 2011-04-01
• 期刊: ENDOCRINOLOGY
• 影响因子: 4.8
• 作者: Anan, Mayumi;Uchihashi, Kazuyoshi;Toda, Shuji
• 通讯作者: Toda, Shuji

Interaction between adipose tissue stromal cells and gastric cancer cells in vitro

• DOI: 10.1007/s00441-011-1144-3
• 发表时间: 2011-05-01
• 期刊: CELL AND TISSUE RESEARCH
• 影响因子: 3.6
• 作者: Nomoto-Kojima, Namie;Aoki, Shigehisa;Toda, Shuji
• 通讯作者: Toda, Shuji

Non-skin mesenchymal cell types support epidermal regeneration in a mesenchymal stem cell or myofibroblast phenotype-independent manner.

非皮肤间充质细胞类型以间充质干细胞或肌成纤维细胞表型独立的方式支持表皮再生。

• 发表时间: 2009
• 期刊: Pathol Int 59
• 作者: Aoki S;Takezawa T;Uchihashi K;Sugihara H;Toda S.
• 通讯作者: Toda S.

Prolonged effect of fluid flow stress on the proliferative activity of mesothelial cells after abrupt discontinuation of fluid streaming

• DOI: 10.1016/j.bbrc.2011.11.051
• 发表时间: 2011-12-16
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Aoki, Shigehisa;Ikeda, Satoshi;Toda, Shuji
• 通讯作者: Toda, Shuji

The air liquid-interface, a skin microenvironment, promotes growth of melanoma cells, but not their apoptosis and invasion, through activation of mitogen-activated protein kinase

气液界面（皮肤微环境）通过丝裂原激活蛋白激酶的激活促进黑色素瘤细胞的生长，但不促进其凋亡和侵袭

• 发表时间: 2010
• 期刊: Acta Histochem Cytochem
• 作者: Yee CH;Aoki S;Uchihashi K;Matsunobu A,Yamasaki F;et.al.
• 通讯作者: et.al.