Angiogenesis and lymphagenesis targeted molecular therapy for cholangiocarcinoma.

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In the present study, we investigated the role of CXCR2 in intrahepatic cholangiocellular carcinoma(ICC). First, expression of CXCR2 is estimated by immunohistochemical staining in ICC using thirty ICC human specimens. Next, the role of CXCR2 was estimated in vitro by proliferation assay, migration assay, or invasion assay. In vivo effect was also estimated using xenograft mice model. As a result, blockage of CXCR2 significantly inhibited proliferation, migration, and invasion of ICC in vitro. Tumor growth of xenograft mice model was also inhibited by CXCR2 antagonist. Our results suggested that CXCR2 act crucial role in the development of ICC. Blockage of CXCR2 may be a promising therapeutic approach for ICC.