The role of Aquaporins in normal gall bladder epithelium and gall bladder cancer

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We examined AQP expression of gall bladder cancer by tissue microarray. In gall bladder cancer, expression of AQP-1 and AQP-5 was observed in 41% and 59% respectively. AQP-5 expression had inverse association with depth of tumor and positive association with gemcitabine sensitivity. Thus, the patients with positive AQP-5 expression had favorable prognosis. SiRNA treatment for AQP-5 positive gall bladder cancer cell line(NOZ-1) inhibited the growth, invasion and mobility of the cells. We identified several miRNAs that can predict Gemcitabine sensitivity of NOZ-1 by microarray analysis. We also identified the target proteins of detected miRNA. Our results suggest that AQP-5 is promising target of gall bladder cancer treatment.