The abnormality of some genes which repair DNA double strand break in lung cancer of the workers with chromate exposure.

我们检测了暴露于铬酸盐或不暴露于铬酸盐的肺癌中DNA修复基因MRE 11的poly（T）区域的异常。我们使用毛细管DNA测序仪进行片段分析。铬酸盐肺癌中MRE 11基因缺失率显著高于非铬酸盐肺癌（7例（25%）对1例（4%），p=0. 05）。033）。在嗜铬细胞癌中，微卫星不稳定性病例有4例（22%）缺失，微卫星稳定性病例有3例（30%）缺失。

We examined abnormality of the poly(T) region of the DNA repair gene, MRE11 in lung cancers with chromate exposure or without exposure. We performed fragment analysis using capillary DNA sequencer. The deletion of MRE11 gene of chromate lung cancers was significantly higher than that of non-chromate lung cancer(7(25%) versus 1(4%), p=0. 033). In chromate lung cancer, microsatellite instability case had 4(22%) deletion, and microsatellite stable case had 3(30%) deletion.