Establishment of disease entity for lung cancer in never-smokers

我们研究了从不吸烟的非小细胞肺癌（NSCLC）和吸烟的NSCLC在分子生物学上的差异。据我们所知，只有在从不吸烟的NSCLC中EGFR突变的发生率较高。另一方面，尽管血清OS（氧化应激）水平与吸烟状态之间没有显著关系，但从不吸烟的NSCLC患者的AOC（抗氧化能力）水平显著低于吸烟者。此外，从不吸烟的NSCLC患者的DNA氧化损伤率显著高于良性疾病患者。结论：从不吸烟的NSCLC患者AOC较低可能是由于DNA过度氧化损伤所致。

We investigated the difference of molecular biology between never-smoked non-small cell lung cancer(NSCLC) and smoked NSCLC. As far as we examined, only high incidence of EGFR mutation in never-smoked NSCLC was recognized. On the other hand, the level of AOC(anti-oxidant capacity) was significantly lower in never-smoked NSCLC patients than in ever-smoked ones although there was no significant relationship between serum OS(oxidative stress) level and smoking status. In addition, the oxidative DNA damage rate of never-smoked NSCLC patients was significantly higher than that of patients with benign diseases. In conclusion, the low AOC in never-smoked NSCLC might be attributed to the excessive oxidative DNA damages.