Roles of FABP and its regulating factors on neurogenesis after ischemia

FABP及其调节因子对缺血后神经发生的作用

• 批准号: 21591834
• 负责人: SUGITA Masao
• 金额: $ 2.91万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591834/
• 关键词: 脳虚血; 脂肪酸結合蛋白; 神経新生; 神経細胞保護

Elucidating the mechanisms of neurogenesis after ischemia is crucial for the development of regenerative therapy for stroke. Brain-type fatty acid binding protein(B-FABP) is supposed to regulate neurogenesis during development and to have a cytoprotective role ; however, the roles on neurogenesis and neuronal injury after ischemia have not been studied well. In this study, we used a mouse forebrain ischemia model, and examined expression change of B-FABP after ischemia. In addition, we evaluated the effects of B-FABP gene knockout on neurogenesis and neuronal injury after ischemia. The current study revealed that B-FABP is expressed in neuronal stem cells, and regulates proliferation of neuronal stem cells under physiological and ischemic conditions, though the role of B-FABP on ischemic neuronal injury is not evident.

阐明缺血后神经发生的机制对于开发中风的再生治疗至关重要。脑型脂肪酸结合蛋白（B-FABP）应该在发育过程中调节神经发生，并具有细胞保护作用。然而，缺血后神经发生和神经元损伤的作用尚未得到很好的研究。在这项研究中，我们使用了小鼠前脑缺血模型，并检查了缺血后B-FABP的表达变化。此外，我们评估了B-FABP基因敲除对缺血后神经发生和神经元损伤的影响。当前的研究表明，B-FABP在神经元干细胞中表达，并且在生理和缺血性条件下调节神经元干细胞的增殖，尽管B-FABP对缺血性神经元损伤的作用尚不明显。

项目成果

Role of Brain Type Fatty Acid Binding Protein in the Transient Brain Ischemia

脑型脂肪酸结合蛋白在短暂性脑缺血中的作用

• 发表时间: 2012
• 作者: Tatsuya Kato;Hideyuki Yoshioka;Yuji Owada;Masao Sugita;Takashi Yagi;Takuma Wakai;and Hiroyuki Kinouchi
• 通讯作者: and Hiroyuki Kinouchi