Systematic strategy for non-invasive neuro-reconstruction

非侵入性神经重建的系统策略

• 批准号: 21591851
• 负责人: FUJIKI Minoru
• 金额: $ 3万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591851/
• 关键词: 脳虚血; 神経細胞死; 神経保護; 虚血耐性; 磁気刺激; 遺伝子発現; BDNF; 神経修復

The present study demonstrates that repetitive transcranial magnetic stimulation(rTMS) induces ischemic tolerance against delayed neuronal death(DND) of hippocampal neurons following an otherwise lethal ischemic insult.Various regimens of rTMS were delivered to adult gerbils at various times prior to an episode of ischemia induced by transient(5min.) bilateral common carotid artery occlusion(BCCO). The extent of delayed neuronal death in the CA1 region of the hippocampus was assessed quantitatively 7 days after the transient ischemic episode.We evaluated whether when rTMS delivered 2-5 days prior to BCCO, delayed neuronal death will be substantially attenuated as reported in ischemic tolerance. A similar degree of neuron sparing will be seen when stimulation was delivered 3, 4, or 5 days prior to BCCO. Effectiveness of rTMS was evaluated whether when stimulation was delivered at frequencies of 25 and 50 Hz.

本研究表明，重复经颅磁刺激（rTMS）可诱导海马神经元在其他致命的缺血性损伤后对延迟神经元死亡（DND）的缺血耐受。在短暂（5min）双侧颈总动脉闭塞（BCCO）引起的缺血发作之前的不同时间，给成年沙鼠提供不同方案的rTMS。短暂性脑缺血发作后7天定量评估海马CA1区的延迟性神经元死亡程度。我们评估了在BCCO前2-5天给予rTMS是否会像缺血耐受中报道的那样，延迟性神经元死亡会显著减弱。在BCCO前3、4或5天进行刺激时，也会看到类似程度的神经元保留。在25 Hz和50 Hz的频率下进行刺激时，评估rTMS的有效性。

项目成果

Electroconvulsive seizure-induced VEGF is correlated with neuroprotective effects against cerebral infarction: Involvement of the phosphatidylinositol-3 kinase/Akt pathway

• DOI: 10.1016/j.expneurol.2010.07.010
• 发表时间: 2010-10-01
• 期刊: EXPERIMENTAL NEUROLOGY
• 影响因子: 5.3
• 作者: Fujiki, Minoru;Abe, Eiji;Kobayashi, Hidenori
• 通讯作者: Kobayashi, Hidenori

Kobayashi H Cognitive alteration after carotid revascularization is correlated with cortical GABA(B)-ergic modulations

Kobayashi H 颈动脉血运重建后的认知改变与皮质 GABA(B) 能调节相关

• 发表时间: 2011
• 期刊: Neurosci Lett
• 影响因子: 2.5
• 作者: Murata K;Fujiki M;Ooba H;Kubo T;Morishige M;Abe T;Ishii K
• 通讯作者: Ishii K

Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus

经颅直流电刺激可减少毛果芸香碱诱发的癫痫持续状态后的惊厥和空间记忆缺陷

• 发表时间: 2011
• 期刊: Behav Brain Res
• 影响因子: 2.7
• 作者: Kamida T;Kong S;Eshima N;Abe T;Fujiki M
• 通讯作者: Fujiki M

The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats

• DOI: 10.1016/j.brainres.2010.02.074
• 发表时间: 2010-05-12
• 期刊: BRAIN RESEARCH
• 影响因子: 2.9
• 作者: Abe, Eiji;Fujiki, Minoru;Kobayashi, Hidenori
• 通讯作者: Kobayashi, Hidenori

器質性精神障害:脳腫瘍術後

器质性精神障碍：脑肿瘤手术后

• 发表时间: 2011
• 作者: 諸藤陽一;中川慎介;宗剛平;林健太郎;陶山一彦;永田泉;丹羽正美;藤木稔
• 通讯作者: 藤木稔