Systematic strategy for non-invasive neuro-reconstruction

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The present study demonstrates that repetitive transcranial magnetic stimulation(rTMS) induces ischemic tolerance against delayed neuronal death(DND) of hippocampal neurons following an otherwise lethal ischemic insult.Various regimens of rTMS were delivered to adult gerbils at various times prior to an episode of ischemia induced by transient(5min.) bilateral common carotid artery occlusion(BCCO). The extent of delayed neuronal death in the CA1 region of the hippocampus was assessed quantitatively 7 days after the transient ischemic episode.We evaluated whether when rTMS delivered 2-5 days prior to BCCO, delayed neuronal death will be substantially attenuated as reported in ischemic tolerance. A similar degree of neuron sparing will be seen when stimulation was delivered 3, 4, or 5 days prior to BCCO. Effectiveness of rTMS was evaluated whether when stimulation was delivered at frequencies of 25 and 50 Hz.