Development of new neuro-protective and normo-thrermic hibernation therapy using intra-cisternal infusion of magnesium sulfate solution

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During mammalian hibernation, magnesium ion(Mg^<2+>) concentration in the brain increases. Based on this fact, we developed the new neuro-protective therapy using cisternal or intra-cerebral magnesium sulfate solution infusion. We demonstrated this therapy suppressed the delayed neuronal death in the hippocampal neurons after the global ischemia. We also showed this neuro-protective effect was not mediated by the suppression of the cerebral blood flow and metabolism.