Pathogenesis and treatment in spinal cord injury without bony disruption

无骨质破坏的脊髓损伤是常见的。老年人容易患上它，因为他们有时会有慢性脊髓压迫症，如颈椎病，颈椎间盘突出和后纵韧带骨化。动态颈部运动包括过伸引起这种间接脊髓损伤，这并不经常导致骨折和脱位。本实验采用慢性压迫脊髓致颈椎过伸的方法建立大鼠脊髓损伤伴骨质破坏的动物模型。我们发现，无骨性断裂的脊髓损伤既取决于脊髓的潜在压迫性退变，也取决于对脊髓的实际冲击。这一现象可以解释无骨性断裂的脊髓损伤的临床异质性。我们正在分析无骨性断裂的脊髓损伤的最佳治疗方法。

Spinal cord injury without bony disruption is common. Elderly people get it easily because they sometimes have chronic spinal cord compression such as cervical spondylosis, cervical disc hernia and ossification of posterior longitudinal ligament. Dynamic neck movement including hyperextension induces this indirect spinal cord injury, which doesn' t often cause bony fracture and dislocation. The mechanism and pathogenesis is not really clear yet.We created the rat model with spinal cord injury with bony disruption, which was induced by cervical hyperextension under the chronic compression of spinal cord. We found that the spinal cord injury without bony disruption depends on potential compressive degeneration of spinal cord as well as actual impact to spinal cord.This phenomenon can explain clinical heterogeneity of spinal cord injury without bony disruption.We are analyzing optimal treatment for spinal cord injury without bony disruption.