Establishment of a Novel Therapeutic Strategy Using Tissue Regeneration for Intractable Spinal Infections.

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Commercial porous bioceramics were partially dissolved in saturated acid solutions and calcium phosphate microcrystals were precipitated on the surfaces of bioceramics by the supersonic dissolution -precipitation method. Calcium phosphate ceramics having excellent bio-absorption and osteoinduction were newly produced by controlling adsorption and release characteristics of bone-morphogenetic protein (rhBMP-2). As a surface modification technique of bioceramics, the supersonic treatment technology using commercial parenteral fluids was established and antibiotic (Cefazolin)-adsorption and release characteristics on the ceramics were clarified. Biomimetic composites of apatite and collagen which were suitable for tissue regeneration were synthesized and the good bio-absorption was recognized. Concerning a quantitative evaluation for patients with intractable spinal infections, severity maps of infection sites were created in 8 cases of intractable spinal infections by using FDG-PET CT.