Elucidation of the roles of SDF-1/CXCR4 signaling on degenerative changes of articular cartilage
Elucidation of the roles of SDF-1/CXCR4 signaling on degenerative changes of articular cartilage
批准号:
21591942
负责人:
ITO Hiromu
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
我们研究了SDF-1/CXCR4信号在关节软骨退行性改变中的作用。SDF-1上调小鼠软骨细胞中II型和X型胶原的表达,但不直接调节X型胶原mRNA的表达。在骨关节炎改变的小鼠膝关节中,SDF-1和CXCR4表达上调。然而,野生型和SDF-1+/之间没有明显的骨关节炎变化。老鼠。
英文摘要
We examined the roles of SDF-1/CXCR4 signaling on degenerative changes of articular cartilages. SDF-1 upregulated type II and type X collagen expression in mouse chondrocytes, but did not directly regulate mRNA expression of type X collagen. In mouse knee joint with osteoarthritic changes, SDF-1 and CXCR4 expression were upregulated. However, there were no significant osteoarthritis changes between wild-type and SDF-1+/. mice.
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Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy.
基质细胞衍生的因子1调节软骨细胞和软骨细胞肥大的肌动蛋白组织。
DOI:
10.1371/journal.pone.0037163
发表时间:
2012
期刊:
PloS one
影响因子:
3.7
作者:
[Murata K, Kitaori T, Oishi S, Watanabe N, Yoshitomi H, Tanida S, Ishikawa M, Kasahara T, Shibuya H, Fujii N, Nagasawa T, Nakamura T, Ito H]
通讯作者:
Ito H
骨治癒における間葵系幹細胞の誘導:ケモカインSDF-1の機能的役割
Aoi 干细胞在骨愈合中的诱导:趋化因子 SDF-1 的功能作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[北折俊之, 伊藤宣, 中村孝志]
通讯作者:
中村孝志
Stromal Cell-Derived Factor/CXCR4 Signaling Is Critical for the Recruitment of Mesenchymal Stem Cells to the Fracture Site During Skeletal Repair in a Mouse Model
基质细胞衍生因子/CXCR4 信号传导对于小鼠模型骨骼修复过程中间充质干细胞募集至骨折部位至关重要
DOI:
--
发表时间:
2009
期刊:
Arthritis and Rheumatism 60
影响因子:
--
作者:
[Kitaori H, Ito H, et al]
通讯作者:
et al
骨治癒を促進させるケモカイン分子Stromal cell-derived factor 1 (SDF-1)
基质细胞衍生因子 1 (SDF-1),一种促进骨愈合的趋化因子分子
DOI:
--
发表时间:
2010
期刊:
臨床整形外科 45
影响因子:
--
作者:
[北折俊之、伊藤宣, 他]
通讯作者:
他
SDF-1はアクチン重合を制御して軟骨の肥大化を促進する
SDF-1调节肌动蛋白聚合并促进软骨肥大
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[村田浩一, 伊藤宣, 中村孝志他]
通讯作者:
中村孝志他
Building the antimicrobials administration strategy by multi-agent model
-
批准号:17H04731
-
项目类别:Grant-in-Aid for Young Scientists (A)
-
资助金额:$15.39万
-
财政年份:2017
-
负责人:ITO Hiromu
-
依托单位:
A Study on the Development of Destinations Utilizing World Heritage Sites
-
批准号:16K08125
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2016
-
负责人:ITO Hiromu
-
依托单位:
Contributing factors to periarticular osteoporosis in rheumatoid arthritis
-
批准号:25462368
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2013
-
负责人:ITO Hiromu
-
依托单位:
SDF-1 plays a role in bone growth and repair by cytoskeleton modulation
-
批准号:19591756
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:ITO Hiromu
-
依托单位:
Clarification of the roles of SDF-1 on mesenchymal stem cells in bone graft healing-toward a clinical application for the improvement of allograft healing-
-
批准号:17591564
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2005
-
负责人:ITO Hiromu
-
依托单位:
海外基金