Characterizing pharmacodynamic interactions of anesthetics on parallel/serial neural circuit model

在并行/串行神经回路模型上表征麻醉剂的药效相互作用

• 批准号: 21591991
• 负责人: KAMINOH Yoshiroh
• 金额: $ 2.83万
• 依托单位: Hyogo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591991/
• 关键词: 薬物相互作用; 麻酔作用機序; 神経ネットワーク; 相乗効果並列回路; 薬力学; 薬物動態; 相乗効果; 並列回路

Producing the anesthetic state is at least a two drug process typically consisting of a hypnotic and an opioid. Models that adequately characterize pharmacodynamic drug interactions are important to understanding anesthetic behavior. We proposed the parallel/serial neural circuit model and characterized its mathematical behavior. The model predicted that the additive interaction occurred only when the mechanism of anesthetics were identical. Some combination of anesthetics showed additive, even though their potencies on molecular level were different. We showed the condition required for the clinically additive interaction using the parallel/serial circuit model.

产生麻醉状态至少是两种药物的过程，通常由催眠药和阿片类药物组成。充分表征药效药物相互作用的模型对于理解麻醉行为非常重要。我们提出了并行/串行神经电路模型并表征了其数学行为。该模型预测，只有当麻醉剂的机制相同时，才会发生相加相互作用。某些麻醉剂组合显示出累加性，尽管它们在分子水平上的效力不同。我们使用并行/串行电路模型展示了临床附加相互作用所需的条件。

项目成果

Is the interaction of inhalation anesthetics additive

吸入麻醉药添加剂有相互作用吗

• 发表时间: 2010
• 作者: Ohse.Y.;Nishimura K.;et al.;西村欣也;Yoshiroh Kaminoh
• 通讯作者: Yoshiroh Kaminoh

Is the interaction of inhalation anesthetics additive?

吸入麻醉药的相互作用是否具有累加性？

• 发表时间: 2010
• 作者: Ohse.Y.;Nishimura K.;et al.;西村欣也;Yoshiroh Kaminoh;Yoshiroh Kaminoh
• 通讯作者: Yoshiroh Kaminoh