Characterizing pharmacodynamic interactions of anesthetics on parallel/serial neural circuit model

产生麻醉状态至少需要两个药物过程，通常包括一种催眠药和一种阿片类药物。充分表征药物相互作用的药效学模型对于理解麻醉行为非常重要。提出了并行/串行神经电路模型，并对其数学行为进行了表征。该模型预测，只有当麻醉药的作用机制相同时，才会发生加性相互作用。某些麻醉药的组合虽然在分子水平上的药效不同，但仍表现出可加性。我们使用并行/串行电路模型展示了临床加性相互作用所需的条件。

Producing the anesthetic state is at least a two drug process typically consisting of a hypnotic and an opioid. Models that adequately characterize pharmacodynamic drug interactions are important to understanding anesthetic behavior. We proposed the parallel/serial neural circuit model and characterized its mathematical behavior. The model predicted that the additive interaction occurred only when the mechanism of anesthetics were identical. Some combination of anesthetics showed additive, even though their potencies on molecular level were different. We showed the condition required for the clinically additive interaction using the parallel/serial circuit model.