The role of adiponectin and resistin in the pathogenesis of postmenopausal metabolic syndrome

为了探讨Adipo和Res在绝经后雌激素缺乏状态中的生理作用，我们研究了Adipo和Res对去卵巢雌性Wistar幼鼠胰岛素敏感性的体内慢性影响。雌激素缺乏状态显著增加了体重，降低了胰岛素敏感性。脂联素改善雌激素缺乏引起的胰岛素抵抗，而抵抗素则加重雌激素缺乏引起的胰岛素抵抗。此外，我们发现AMPK在肌肉和肝脏中是一个关键的分子参与者。这些结果表明，随着女性年龄的增长，尤其是在绝经后，胰岛素抵抗与糖尿病发病率的增加有关。

To investigate the physiological role of Adipo and Res in the postmenopausal, estrogen-deficient state, we studied the chronic in vivo effect of Adipo and Res on insulin sensitivity in young ovariectomized female Wistar rats. Estrogen-deficient state had significantly increased body weight and decreased insulin sensitivity. Adiponectin improves the estrogen deficiency induced insulin resistance, whereas resistin exacerbates the estrogen deficiency induced insulin resistance. Furthermore, we found that AMPK is a key molecule player in muscle and liver.These results that the insulin resistance has been involved in the incidence of diabetes increases as women age, especially after menopause.