The role of adiponectin and resistin in the pathogenesis of postmenopausal metabolic syndrome

为了研究Adipo和Res在绝经后雌激素缺乏状态下的生理作用，我们研究了Adipo和Res对年轻卵巢切除雌性Wistar大鼠胰岛素敏感性的慢性体内影响。雌激素缺乏状态显著增加体重，降低胰岛素敏感性。脂联素改善雌激素缺乏诱导的胰岛素抵抗，而抵抗素加剧雌激素缺乏诱导的胰岛素抵抗。此外，我们发现AMPK是肌肉和肝脏的关键分子。这些结果表明，胰岛素抵抗与糖尿病的发病率随着女性年龄的增长而增加，尤其是绝经后。

To investigate the physiological role of Adipo and Res in the postmenopausal, estrogen-deficient state, we studied the chronic in vivo effect of Adipo and Res on insulin sensitivity in young ovariectomized female Wistar rats. Estrogen-deficient state had significantly increased body weight and decreased insulin sensitivity. Adiponectin improves the estrogen deficiency induced insulin resistance, whereas resistin exacerbates the estrogen deficiency induced insulin resistance. Furthermore, we found that AMPK is a key molecule player in muscle and liver.These results that the insulin resistance has been involved in the incidence of diabetes increases as women age, especially after menopause.