Analysis of the role of MPA as a molecular-targeted therapy in endometrial cancer.

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The aims of our study were to evaluate the role of MPA for the regulation of tumor progression. In type 1 endometrial cancer cell line, MPA did not activate both ERK and Akt, However, ERK and Akt were phosphorylated by MPA in type 2 cell line. Interestingly, estradiol(E2) activated ERK and Akt in both cell lines. Therefore, GPR30, a membrane receptor for E2, might be a key molecule for tumor progression in both type 1 and type 2 endometrial cancers. The activation of GPR30 was associated to tumor proliferation via up regulation of cyclin D1.Furthermore, epithelial-mesenchymal-transition(EMT) is recently identified as an important step in the invasion and metastasis of cancer. Our data indicate that reduced E-cadherin and nuclear expression of Snail and Slug have a prognostic impact in endometrial cancer. Therefore, to clarify and control of EMT signaling is a promising molecular targeting therapy in endometrial cancer.