Olfactory regenerative medicine by granulocyte-colony stimulating factor

粒细胞集落刺激因子嗅觉再生医学

• 批准号: 21592176
• 负责人: NISHIZAKI Kazunori
• 金额: $ 2.91万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592176/
• 关键词: 嗅細胞; 再生; 骨髄移植; G-CSF; メチマゾール; 嗅組織幹細胞; 嗅球; シナプス形成

A statistical analysis demonstrated significantly that the early administration of G-CSF(granulocyte-colony stimulating factor) was appropriate to increase the engraftment rate of bone marrow-derived cells into the olfactory epithelium. Moreover, cells with double-immunostaining for GFP(green fluorescence protein) and OMP(olfactory marker protein) and so on were found in the olfactory epithelium of recipient mice, which suggested that bone marrow-derived cells are engrafted as stem cells of the olfactory tissue. Thus, the early administration of G-CSF after insult to the olfactory tissue is suggested to be effective to olfactory regenerative medicine using bone marrow cells.

统计分析表明，早期给予G-CSF（粒细胞集落刺激因子）可提高骨髓源性细胞在嗅上皮内的植入率。此外，受体小鼠嗅上皮中发现了绿色荧光蛋白（GFP）和嗅觉标记蛋白（OMP）等双免疫染色细胞，提示骨髓源性细胞作为嗅觉组织的干细胞被移植。因此，嗅觉组织损伤后早期给予G-CSF对骨髓细胞嗅觉再生医学有效。

项目成果

The early administration of granulocyte colony-stimulating factor increases the engraftment of transplanted bone marrow-derived cells into the olfactory epithelium damaged by methimazole

粒细胞集落刺激因子的早期施用可增加移植的骨髓来源细胞在甲硫咪唑损伤的嗅觉上皮中的植入

• DOI: 10.4193/rhin09.100
• 发表时间: 2010
• 期刊: Rhinology
• 影响因子: 7.2
• 作者: Nishizaki K;Yoshinobu J;Tsujigiwa H;Orita Y;Yamada M
• 通讯作者: Yamada M

Olfactory Tissue and Regeneration Medicine

嗅觉组织与再生医学

• 发表时间: 2011
• 作者: 平岡政信;その他;Nishizaki K
• 通讯作者: Nishizaki K

嗅球における移植骨髄細胞の役割

移植的骨髓细胞在嗅球中的作用

• 发表时间: 2011
• 期刊: 日鼻科
• 作者: 野田洋平;西崎和則;吉延潤子;折田頼尚
• 通讯作者: 折田頼尚