Olfactory regenerative medicine by granulocyte-colony stimulating factor

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A statistical analysis demonstrated significantly that the early administration of G-CSF(granulocyte-colony stimulating factor) was appropriate to increase the engraftment rate of bone marrow-derived cells into the olfactory epithelium. Moreover, cells with double-immunostaining for GFP(green fluorescence protein) and OMP(olfactory marker protein) and so on were found in the olfactory epithelium of recipient mice, which suggested that bone marrow-derived cells are engrafted as stem cells of the olfactory tissue. Thus, the early administration of G-CSF after insult to the olfactory tissue is suggested to be effective to olfactory regenerative medicine using bone marrow cells.