Expression and clinical analysis of a novel cancer/testis antigen, TEX101 in head and neck squamous cell carcinoma

新型癌症/睾丸抗原 TEX101 在头颈鳞状细胞癌中的表达和临床分析

• 批准号: 21592206
• 负责人: YOSHITAKE Hiroshi
• 金额: $ 3万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592206/
• 关键词: TEX101; 癌・精巣抗原; 頭頸部癌; GPIアンカー型タンパク質; 癌マーカー; Ly6K

A germ cell-marker glycoprotein, TEX101 is expressed not only in germ cells but also in cancer cells from patients with head and neck squamous cell carcinoma, demonstrating that this molecule is a novel cancer/testis antigen. The rate of lymph nodes metastasis tends to be low in the TEX101-positive HNSCC patients, compared to the patients with cancer of weak positive and negative expression of TEX101. TEX101 may be useful as a biological marker and a target for cancer therapy.

生殖细胞标记糖蛋白TEX 101不仅在生殖细胞中表达，而且在头颈部鳞状细胞癌患者的癌细胞中表达，表明该分子是一种新的癌症/睾丸抗原。与TEX 101弱阳性和阴性表达的肿瘤患者相比，TEX 101阳性的HNSCC患者的淋巴结转移率往往较低。TEX 101可用作癌症治疗的生物标记物和靶点。

项目成果

Relationship between olfactory acuity and peak expiratory flow during postoperative follow-up in chronic rhinosinusitis associated with asthma

慢性鼻-鼻窦炎哮喘患者术后随访中嗅觉敏锐度与呼气峰流量的关系

• 发表时间: 2010
• 期刊: Ann Otol Rhinol Laryngol 119(11)
• 作者: Ikeda K;Yokoi H;Kusunoki T;Saitoh T;Yao T;Kase K;Minekawa A;Inoshita A;Kawano K
• 通讯作者: Kawano K

Bacterial contamination of multiple-use atomizers commonly used in Japan

日本常用多用雾化器细菌污染

• 发表时间: 2009
• 期刊: Indian J Otolaryngol Head Neck Surg 61
• 作者: Ikeda K;Sakai Y;Haruyama T;Misawa N;Misawa N;Hori S;Kusunoki T;Furukawa M;Yokoi H;Yokoi N;Ichihari Y;Kawano K;Matsumoto F;Hayashi C;Narui Y;Iizuka T;Ito S;Inoshita A;Kasai M;Saito T;Minekawa A;Oba S;Cho Y
• 通讯作者: Cho Y

Bacteriology of recurrent exacerbation of postoperative course in chronic rhinosinusitis in relation to asthma

• DOI: 10.1016/j.anl.2010.10.009
• 发表时间: 2011-08-01
• 期刊: AURIS NASUS LARYNX
• 影响因子: 1.7
• 作者: Ikeda, Katsuhisa;Yokoi, Hidenori;Kawano, Kenji
• 通讯作者: Kawano, Kenji

Distribution of molecular epitope for Ts4, an anti-sperm auto-monoclonal antibody in the fertilization process.

受精过程中抗精子自体单克隆抗体 Ts4 的分子表位分布。

• 发表时间: 2009
• 期刊: J Reprod Dev. 55
• 作者: Shirai Y;Yoshitake H;Maruyama M;Takamori K;Ogawa H;Hasegawa A;Araki Y.
• 通讯作者: Araki Y.

Possible Contribution of Circulating Blood Cells to Embryo Implantation

循环血细胞对胚胎植入的可能贡献

• 发表时间: 2010
• 期刊: Indian Journal of Physiology and Pharmacology
• 作者: H Fujiwara;et al.
• 通讯作者: et al.