Expression and clinical analysis of a novel cancer/testis antigen, TEX101 in head and neck squamous cell carcinoma
Expression and clinical analysis of a novel cancer/testis antigen, TEX101 in head and neck squamous cell carcinoma
批准号:
21592206
负责人:
YOSHITAKE Hiroshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
生殖细胞标记糖蛋白TEX 101不仅在生殖细胞中表达,而且在头颈部鳞状细胞癌患者的癌细胞中表达,表明该分子是一种新的癌症/睾丸抗原。与TEX 101弱阳性和阴性表达的肿瘤患者相比,TEX 101阳性的HNSCC患者的淋巴结转移率往往较低。TEX 101可用作癌症治疗的生物标记物和靶点。
英文摘要
A germ cell-marker glycoprotein, TEX101 is expressed not only in germ cells but also in cancer cells from patients with head and neck squamous cell carcinoma, demonstrating that this molecule is a novel cancer/testis antigen. The rate of lymph nodes metastasis tends to be low in the TEX101-positive HNSCC patients, compared to the patients with cancer of weak positive and negative expression of TEX101. TEX101 may be useful as a biological marker and a target for cancer therapy.
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慢性鼻-鼻窦炎哮喘患者术后随访中嗅觉敏锐度与呼气峰流量的关系
DOI:
--
发表时间:
2010
期刊:
Ann Otol Rhinol Laryngol 119(11)
影响因子:
--
作者:
[Ikeda K, Yokoi H, Kusunoki T, Saitoh T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K]
通讯作者:
Kawano K
DOI:
--
发表时间:
2009
期刊:
Indian J Otolaryngol Head Neck Surg 61
影响因子:
--
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[Ikeda K, Sakai Y, Haruyama T, Misawa N, Misawa N, Hori S, Kusunoki T, Furukawa M, Yokoi H, Yokoi N, Ichihari Y, Kawano K, Matsumoto F, Hayashi C, Narui Y, Iizuka T, Ito S, Inoshita A, Kasai M, Saito T, Minekawa A, Oba S, Cho Y]
通讯作者:
Cho Y
DOI:
10.1016/j.anl.2010.10.009
发表时间:
2011-08-01
期刊:
AURIS NASUS LARYNX
影响因子:
1.7
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[Ikeda, Katsuhisa, Yokoi, Hidenori, Kawano, Kenji]
通讯作者:
Kawano, Kenji
Distribution of molecular epitope for Ts4, an anti-sperm auto-monoclonal antibody in the fertilization process.
受精过程中抗精子自体单克隆抗体 Ts4 的分子表位分布。
DOI:
--
发表时间:
2009
期刊:
J Reprod Dev. 55
影响因子:
--
作者:
[Shirai Y, Yoshitake H, Maruyama M, Takamori K, Ogawa H, Hasegawa A, Araki Y.]
通讯作者:
Araki Y.
DOI:
--
发表时间:
2010
期刊:
Indian Journal of Physiology and Pharmacology
影响因子:
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[H Fujiwara, et al.]
通讯作者:
et al.
共 37 条
Analysis of gonad developmental mechanisms concerning of a germ cell-specific antigen, TEX101 through gene transfer
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批准号:19591912
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2007
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负责人:YOSHITAKE Hiroshi
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依托单位:
海外基金