Development of devices for retinal protection

视网膜保护装置的开发

• 批准号: 21592214
• 负责人: ABE Toshiaki
• 金额: $ 2.91万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592214/
• 关键词: 網膜保護; デバイス; ドラックデリバリーシステム; 新生血管; コラーゲン; PEG; ドラッグデリバリーシステム

We aimed the creation of a new device that secretes a drug for retinal protection and suppresion of choraidal neovascularization (CNV). We also aimed the sustained delivery of the drug, safety of the device and easily to be taken out the devices.The devices were made from a sustained-release film and the reservoir using triethylene glycol dimethacrylate (TEGDM), polyethylene glycol dimethacrylate (PEGDM), and collagen particles with UV irradiation. When we used vasohibin-1 for the loaded drug in the devices, the released vasohibin-1 was found to inhibit the proliferation of endothelial cells (HUVEC)in vitro. We put the device on rat sclera and examined for a rat model of CNV using intense photocoagulation, and the effect was considered significantly when compared to that of non-vasohibin releasing device by fluorescein photography and measurement of the CNV area. Fabrication of the device can make the results exactly the sustained release of drug. We may be abe to use the device from transscleral drug delivery one for retinal diseases.

我们的目标是创造一种新的装置，分泌一种药物，用于视网膜保护和抑制脉络膜新生血管（CNV）。本研究以缓释膜和贮库为材料，分别采用三甘醇二甲基丙烯酸酯（TEGDM）、聚乙二醇二甲基丙烯酸酯（PEGDM）和胶原蛋白颗粒，经紫外线照射制成缓释装置。当我们在装置中使用vasohibin-1作为负载药物时，发现释放的vasohibin-1在体外抑制内皮细胞（HUVEC）的增殖。我们将该装置放在大鼠巩膜上，并使用强烈的光凝固法检查大鼠CNV模型，通过荧光素照相和CNV面积测量，与非血管收缩素释放装置相比，认为其效果显著。该装置的研制可使药物的缓释效果确切。我们可能会使用的装置，从经巩膜给药一个视网膜疾病。

项目成果

経強膜ドラッグデリバリーシステムによる網膜神経保護の試み

尝试使用经巩膜给药系统保护视网膜神经

• 发表时间: 2011
• 作者: 永井展裕;熊坂典浩;大浪英之;川島丈明;梶弘和;西澤松彦;阿部俊明
• 通讯作者: 阿部俊明

持続性ドラックデリバーシステム

可持续药物输送系统

• 发表时间: 2010

Nishida K Difficulty in Inserting 25-and 23-gauge Trocar-cannula during Vitrectomy

Nishida K 玻璃体切除术中插入 25 号和 23 号套管针的困难

• 发表时间: 2011
• 期刊: Ophthalmologica
• 影响因子: 2.6
• 作者: Kunikata H Nitta F;Meguro Y;Aizawa N;Hariya T;Chiba N;Abe T;Nishida K
• 通讯作者: Nishida K

Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor

Vasohibin-1（血管内皮源性血管生成抑制剂）对脉络膜新生血管的抑制

• 发表时间: 2011
• 期刊: Invest Ophthalmol Vis Sci Feb 23
• 作者: Ryosuke Wakusawa;Toshiaki Abe;Hajime Sato;Hikaru Sonoda;Masaaki Sato;Yuuichi Mitsuda;Tomoaki Takakura;Tomi Fukushima;Hideyuki Onami;Nobuhiro Nagai;Yumi Ishikawa;et al
• 通讯作者: et al

Evaluation of retinal degeneration in P27KlP1 null mice.

P27KlP1 缺失小鼠视网膜变性的评估。

• 发表时间: 2010
• 期刊: Adv Exp Med Biol. 664
• 作者: Tokita-Ishikawa Y;Wakusawa R;Abe T
• 通讯作者: Abe T