Investigation of susceptibility genes for primary open-angle glaucoma-Analysis of ESR2 gene polymorphisms-

原发性开角型青光眼易感基因调查-ESR2基因多态性分析-

• 批准号: 21592221
• 负责人: MABUCHI Fumihiko
• 金额: $ 3万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592221/
• 关键词: 緑内障; estrogen receptor beta; ESR2; 遺伝学; 眼圧; 遺伝子多型; POAG; SNP

Single nucleotide polymorphisms(SNPs) covering the whole region of estrogen receptor beta(ESR2) gene were genotyped in female patients with primary open-angle glaucoma(POAG) and the control subjects without glaucoma, and novel SNPs associated with intraocular pressure(IOP) were identified. These results strongly suggest that the ESR2 gene polymorphisms are associated with IOP regulation in women and IOP elevation in female patients with POAG.

对女性原发性开角型青光眼（POAG）患者和非青光眼对照组雌激素受体β（ESR2）基因全区域的单核苷酸多态性（SNPs）进行基因分型，并发现与眼压（IOP）相关的新SNPs。这些结果有力地表明，ESR2基因多态性与女性眼压调节和女性POAG患者的眼压升高有关。

项目成果

Genome-wide Association Study of Normal Tension Glaucoma: Common Variants in SRBD1 and ELOVL5 Contribute to Disease Susceptibility

• DOI: 10.1016/j.ophtha.2009.12.001
• 发表时间: 2010-07-01
• 期刊: OPHTHALMOLOGY
• 影响因子: 13.7
• 作者: Meguro, Akira;Inoko, Hidetoshi;Inoko, Hidetoshi
• 通讯作者: Inoko, Hidetoshi

Writing committee for the normal tension glaucoma genetic study group of Japan glaucoma society. Genome-wide association study of normal tension glaucoma : common variants in SRBD1 and ELOVL5 contribute to disease susceptibility

日本青光眼学会正常眼压性青光眼遗传学研究组编写委员会。

• 发表时间: 2010
• 期刊: Ophthalmology
• 影响因子: 13.7

Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma

女性原发性开角型青光眼患者雌激素受体β基因多态性与眼压升高的关系

• 发表时间: 2010
• 期刊: Am J Ophthalmol
• 影响因子: 4.2
• 作者: Mabuchi F;Sakurada Y;Kashiwagi K;Yamagata Z;Iijima H;Tsukahara S
• 通讯作者: Tsukahara S

Polymorphisms in ARMS2 (LOC387715) and LOXL1 Genes in the Japanese With Age-Related Macular Degeneration

• DOI: 10.1016/j.ajo.2010.08.048
• 发表时间: 2011-03-01
• 期刊: AMERICAN JOURNAL OF OPHTHALMOLOGY
• 影响因子: 4.2
• 作者: Fuse, Nobuo;Mengkegale, Mingge;Nishida, Kohji
• 通讯作者: Nishida, Kohji

Estrogen receptor beta遺伝子多型と眼圧の関連について

关于雌激素受体β基因多态性与眼压的关系

• 作者: 間渕文彦;櫻田庸一;柏木賢治;山縣然太朗;飯島裕幸;塚原重雄
• 通讯作者: 塚原重雄