Vascular maturation and its association with hematopoietic stem dells in intraocular neovascularization

除了先前报道的血管内皮生长因子外，基质细胞衍生因子1α(SDF-1α)及其诱导的内皮祖细胞在多种眼内新生血管疾病（如增殖性糖尿病视网膜病变和新生血管性青光眼）的新生血管和血管成熟中发挥重要作用。肌腱源性抗血管生成因子-肌腱调节素通过与这些因子的相互作用抑制眼内新生血管活动。

In addition to the previously reported vascular endothelial growth factor, Stromal cell-derived factor 1α(SDF-1α) and its inducing endothelial progenitor cells can play important roles in neovascularization and vascular maturation in a variety of intraocular neovascular diseases such as proliferative diabetic retinopathy and neovascular glaucoma. The tendon-derived anti-angiogenic factor, tenomodulin, can suppress the intraocular neovascular activities via the interaction with these factors.