Vascular maturation and its association with hematopoietic stem dells in intraocular neovascularization

眼内新生血管中血管成熟及其与造血干细胞的关系

• 批准号: 21592230
• 负责人: OSHIMA Yusuke
• 金额: $ 2.58万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592230/
• 关键词: 血管内皮増殖因子; 造血系幹細胞; テノモジュリン; 眼内血管新生; 増殖糖尿病網膜症; 血管新生緑内障; 未熟児網膜症; VEGF; SDF1α; 造血幹細胞; 血管前駆細胞; 抗VEGF抗体; 抗SDF1α抗体; 血管線維増殖膜; SDF1□; 血管血管; 新生血管増殖膜

In addition to the previously reported vascular endothelial growth factor, Stromal cell-derived factor 1α(SDF-1α) and its inducing endothelial progenitor cells can play important roles in neovascularization and vascular maturation in a variety of intraocular neovascular diseases such as proliferative diabetic retinopathy and neovascular glaucoma. The tendon-derived anti-angiogenic factor, tenomodulin, can suppress the intraocular neovascular activities via the interaction with these factors.

除已报道的血管内皮生长因子外，基质细胞衍生因子-1 α（SDF-1α）及其诱导的内皮祖细胞在增殖性糖尿病视网膜病变和新生血管性青光眼等多种眼内新生血管疾病的新生血管形成和血管成熟中也发挥重要作用。腱源性抗血管生成因子tenomodulin通过与这些因子相互作用而抑制眼内新生血管的生成。

项目成果

Advanced vitreoretinal surgical techniques and pharmacotherapy : pros and cons of anti-VEGF adjuncts for diabetic vitrectomy

先进的玻璃体视网膜手术技术和药物治疗：糖尿病玻璃体切除术抗VEGF辅助剂的利弊

• 发表时间: 2012
• 作者: Arita R;Hata Y;et al.;Oshima Y.
• 通讯作者: Oshima Y.

Foveal Microstructure and Visual Acuity in Surgically Closed Macular Holes: Spectral-Domain Optical Coherence Tomographic Analysis

• DOI: 10.1016/j.ophtha.2010.01.017
• 发表时间: 2010-09-01
• 期刊: OPHTHALMOLOGY
• 影响因子: 13.7
• 作者: Wakabayashi, Taku;Fujiwara, Maiko;Oshima, Yusuke
• 通讯作者: Oshima, Yusuke

Principales and instrumentations. Vitreo-retinal Surgery Progress III. Series : Essentials in Ophthalmology

原理和仪器。

• 发表时间: 2009
• 作者: Oshima Y;TanoY
• 通讯作者: TanoY

Foveal Microstructure and Visual Acuity after Retinal Detachment Repair Imaging Analysis by Fourier-Domain Optical Coherence Tomography

• DOI: 10.1016/j.ophtha.2008.10.001
• 发表时间: 2009-03-01
• 期刊: OPHTHALMOLOGY
• 影响因子: 13.7
• 作者: Wakabayashi, Taku;Oshima, Yusuke;Tano, Yasuo
• 通讯作者: Tano, Yasuo

増殖糖尿病網膜症に対する治療戦略:bevacizumabの功罪

增殖性糖尿病视网膜病变的治疗策略：贝伐珠单抗的优点和缺点

• 发表时间: 2009
• 作者: Inoue R;Sawa M;Tsujikawa M;Gomi F.;大島佑介
• 通讯作者: 大島佑介