Hemodynamic analysis of parafoveal capillaries in eyes with diabetes mellitus using adaptive optics scanning laser ophthalmoscopy

AO-SLO清晰地显示黄斑区域内的高反射性颗粒。经详细分析，这些增生性颗粒是由视网膜毛细血管中流动的白细胞产生的。在AO-SLO的电影中，可以看到白细胞伴随许多红细胞形成红细胞叠连。我们测量了健康人和糖尿病患者黄斑毛细血管中白细胞的速度，发现两组白细胞的速度没有差异。然而，糖尿病患者的白细胞的速度表现出广泛的多样性，一些白细胞似乎以明显降低的速度流动。这种多样性可能与糖尿病视网膜病变的早期变化有关。对这种变化的评估可能有助于在医生通过眼底检查做出诊断之前检测糖尿病视网膜病变。

AO-SLO shows clearly hyperreflrctive particles moving within the macular area. By detailed analysis, these hyperreflrctive particles are showed to be derived from leukocytes flowing in the retinal capillaries. In the movies in AO-SLO, leukocytes were seen to accompany many erythrocytes in rouleau formation. We measured the velocities of leukocytes in the macular capillaries of healthy subjects and diabetic patients and found no differences in velocities of leukocytes in both groups. However, diabetic patients showed a wide diversity in the velocities of leukocytes and some leukocytes seemed to flow in a markedly reduced speed. This diversity may be associated with a very early change of diabetic retinopathy. The evaluation of this change might be of use to detect diabetic retinopathy before physicians can make a diagnosis with the use of fundus examination.