Integrated study on the pathophysiology and treatment of pancreaticobiliary maljunction

基于蛋白质塞理论，我们开发了一种新的内窥镜胆道引流(EBD)疗法，用于治疗持续或加重的胰胆管连接不良症状的患者。胰胆管连接不良的致癌机制尚不清楚。基因芯片分析和实时定量聚合酶链式反应检测到5个基因表达上调，1个基因表达下调，包括UCA1、DUOX2、DUOXA2、ID1、BMF和GP2。UCA1是一种非编码RNA，是一种癌胎儿基因，它的上调可能在胆道癌的发生中起重要作用

Based on the protein plug theory, we have developed a new therapy of endoscopic biliary drainage(EBD) for patients with persistent or exacerbated symptoms of pancreaticobiliary maljunction. The mechanism of carcinogenesis of pancreaticobiliary maljunction remains unknown. Microarray analysis and Real-time PCR identified 5 upregulatedgenes and one downregulated gene, including UCA1, DUOX2, DUOXA2, ID1, BMF, and GP2. UCA1, a noncoding RNA, is an oncofetal gene, and its upregulation may be important for biliary carcinogenesis