Integrated study on the pathophysiology and treatment of pancreaticobiliary maljunction

基于蛋白塞理论，我们开发了一种内镜胆道引流（EBD）的新治疗方法，用于持续或加重胰胆道异常症状的患者。胰胆管异常的癌变机制尚不清楚。微阵列分析和Real-time PCR鉴定出5个上调基因和1个下调基因，包括UCA1、DUOX2、DUOXA2、ID1、BMF和GP2。UCA1是一种非编码RNA，是一种癌胎基因，其上调可能对胆道癌的发生有重要意义

Based on the protein plug theory, we have developed a new therapy of endoscopic biliary drainage(EBD) for patients with persistent or exacerbated symptoms of pancreaticobiliary maljunction. The mechanism of carcinogenesis of pancreaticobiliary maljunction remains unknown. Microarray analysis and Real-time PCR identified 5 upregulatedgenes and one downregulated gene, including UCA1, DUOX2, DUOXA2, ID1, BMF, and GP2. UCA1, a noncoding RNA, is an oncofetal gene, and its upregulation may be important for biliary carcinogenesis