Anti-inflammatory effect of hyperthermia on endothelial cells-temperature dependency and systemic response

高热被认为是一个重要的条件，可能会导致多器官衰竭（MOF）与内皮细胞损伤。我们证明，内皮细胞可能表现出细胞因子白细胞介素（IL）-8释放的温度依赖性机制和抑制细胞因子蛋白的产生后，短暂的高温刺激，即使IL-8 mRNA的水平增加，观察。由于短暂高温后IL-6或IL-8的调节具有长期效应，在高温刺激下孵育内皮细胞后，其mRNA表达增加，随后该过程可能导致中性粒细胞浸润到损伤组织中，这反过来又可能通过增强继发性损伤过程而使结果恶化。

Hyperthermia is considered an important condition that may contribute to multiple organ failure(MOF) associated with endothelial cell damage. We demonstrated that endothelial cells may exhibit a temperature-dependent mechanism of cytokine interleukin(IL)-8releases and the suppression of cytokine protein production after transient hyperthermia stimuli even though an increased level of IL-8mRNA was observed. As there is a long-term effect of IL-6or8modulation after transient hyperthermia with increasing in mRNA expression after incubating endothelial cells under high-temperature stimuli, then the process might subsequently lead to neutrophil infiltration into the injured tissue, which in turn could worsen the outcome by enhancing secondary injury processes.