Histological examination about the role of Runx2 in tertiary dentin formation

本研究的目的是阐明Runx2在三级牙本质形成中的作用，Runx2是成骨细胞分化的重要转录因子。我们检测了人类牙齿的三级牙本质和小鼠磨牙实验形成的修复性牙本质，免疫组织化学证明Runx2在三级牙本质形成细胞中表达，骨组织中高度存在的骨桥蛋白和骨钙素也在三级牙本质中表达。因此，我们认为Runx2在三级牙本质形成中起作用。

The aim of this study is to clarify the role of Runx2, which is an essential transcription factor for osteoblast differentiation, in tertiary dentin formation. We examined tertiary dentin of human teeth, and reparative dentin that was experimentally formed in mouse molars, and have immunohistochemically demonstrated that Runx2 was expressed in the formative cells of tertiary dentin, and osteopontin and osteocalcin, which were highly present in bone tissue, were also expressed in tertiary dentin. Thus, it was suggested that Runx2 plays a role in tertiary dentin formation.