Regulatory mechanisms of gustatory circuit and feeding behavior by the neural Ig receptors

神经 Ig 受体对味觉回路和进食行为的调节机制

• 批准号: 21592376
• 负责人: KONDO Masahiro
• 金额: $ 2.91万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592376/
• 关键词: 神経回路形成; 味嗜好性; 細胞接着分子; Ig受容体; 選択的スプライシング

Dscam, which encodes a neural Ig receptor, can generate more than 38,000 isoforms via alternative splicing. Dscam knock-down in taste cells induced loss of synapses between taste cells and secondary neurons. These flies showed reduced appetite or a decreased behavioral avoidance to bitter compounds. In contrast, the revertant flies with 22,000 isoforms showed indistinguishable feeding behavior with wildtype. Our results suggest that Dscam is essential for synapse formation in gustatory circuits and for the feeding behavior, but the full set of Dscam isoforms may not be required.

Dscam编码一种神经Ig受体，可以通过选择性剪接产生超过38,000种同种异构体。味觉细胞中的Dscam敲除导致味觉细胞和次级神经元之间的突触丢失。这些果蝇表现出食欲下降或对苦味化合物的行为回避减少。相比之下，具有22,000个同种异构体的反向果蝇与野生型的摄食行为没有区别。我们的研究结果表明，Dscam在味觉回路的突触形成和摄食行为中是必不可少的，但全套的Dscam亚型可能不是必需的。

项目成果

Involvement of GluR2 and GluR3 subunit C-termini in the trigeminal spinal subnucleus caudalis and C1-C2 neurons in trigeminal neuropathic pain.

• DOI: 10.1016/j.neulet.2010.12.060
• 发表时间: 2011-03-10
• 期刊: Neuroscience letters
• 影响因子: 2.5
• 作者: Miyamoto M;Tsuboi Y;Takamiya K;Huganir RL;Kondo M;Shinoda M;Oi Y;Iwata K
• 通讯作者: Iwata K

Regulatory mechanisms of feeding behavior by the neural Ig receptors

神经 Ig 受体对摄食行为的调节机制

• 发表时间: 2010
• 作者: 佐藤慶太郎;成田貴則;福島美和子;伊藤龍朗;泉福英信;杉谷博士.;近藤真啓
• 通讯作者: 近藤真啓

Characterization of individual mechanosensory neurons based on theiraxonal structures in Drosophila

基于果蝇轴突结构的单个机械感觉神经元的表征

• 发表时间: 2011
• 作者: Fujita-Yoshigaki J;Qi B;Narita T;Sugiya H;キンキンター;吉村健太郎(宮本洋一);Yasuda M
• 通讯作者: Yasuda M

PKCγ in Vc and C1/C2 is Involved in Trigeminal Neuropathic Pain

• DOI: 10.1177/0022034511401406
• 发表时间: 2011-06-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Nakajima, A.;Tsuboi, Y.;Iwata, K.
• 通讯作者: Iwata, K.

PKCgamma in Vc and C1/C2 is involved in trigeminal neuropathic pain

Vc 和 C1/C2 中的 PKCgamma 参与三叉神经病理性疼痛

• 发表时间: 2011
• 期刊: J Dent Res
• 影响因子: 7.6
• 作者: Nakajima A;Tsuboi Y;Suzuki I;Honda K;Shinoda M;Kondo M;Matsuura S;Shibuta K;Yasuda M;Shimizu N;Iwata K
• 通讯作者: Iwata K