Study of mechanism of occurrence and increased risk factor of BRONJ

BRONJ发生的危险因素为拔牙手术、褥疮和牙周病。对于BRONJ预后增加的危险因素，NTX骨吸收标志物和BAP成骨细胞标志物是有用的。结果表明，BP对成骨细胞增殖有抑制作用，且具有剂量依赖性。骨密度测定FANTOM（骨密度标记物）显示BRONJ预后，不良预后值超过450mg/ml。

Occurrence risk factor of BRONJ revealed the operation of extraction of teeth, decubital ulcer and periodontosis. As for the increased risk factor of prognosis of BRONJ, bone absorption marker of NTX and osteoblastic marker of BAP was useful. This research revealed BP inhibit of proliferation of osteoblast, dose dependency. Bone density with use of FANTOM(marker of bone density) showed the prognosis of BRONJ, the bad prognosis of value was over the 450mg/ml.