Analysis of miRNA expression profiles and mechanism of epigenetics in rat tongue carcinogenesis

大鼠舌癌发生过程中miRNA表达谱及表观遗传学机制分析

• 批准号: 21592393
• 负责人: TANUMA Jun-ishi
• 金额: $ 3万
• 依托单位: Asahi University (2010-2011)Kagoshima University (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592393/
• 关键词: ラット舌癌; 舌癌モデル; メチル化; 前癌病変; hnRNP K; Real-time PCR; アレイ; 舌癌; siRNA; ノチル化; miRNA

Oral cancer is one of the most commonly diagnosed malignancies worldwide. Its dismal five-year survival rate of. 50% has barely changed for decades. A better understanding of the molecular basis of tumorigenesis-with particular emphasis on disease initiation and progression-is needed to improve clinical outcomes, since this will facilitate the development of drugs and management strategies based on the specific genetic changes underpinning disease behaviors. MicroRNAs(miRNAs), a class of short non-coding RNAs that down-regulate gene expression, have been demonstrated to play essential roles in human cancers. miRNA deregulation has been observed in many tumor types and is implicated in oncogenic cell processes, including proliferation, survival, apoptosis, metastasis, and chemoresistance. In addition, miRNA alterations have been associated with specific clinical phenotypes such as disease progression or recurrence, development of metastases, and post-operative survival. Recent studies have explored the utility of miRNAs as diagnostic and prognostic tools and as potential therapeutic targets. Herein, we discuss miRNA biology and provide a summary of the key findings on the role of miRNAs in rat tongue carcinogenesis.

口腔癌是全世界最常见的恶性肿瘤之一。其令人沮丧的五年存活率。50%的比例几十年来几乎没有变化。需要更好地了解肿瘤发生的分子基础--特别是疾病的发生和发展--以改善临床结果，因为这将促进基于支撑疾病行为的特定基因变化的药物和管理策略的开发。MicroRNAs(MiRNAs)是一类下调基因表达的短非编码RNA，已被证明在人类癌症中发挥重要作用。MiRNA去调控在许多肿瘤类型中被观察到，并且与肿瘤细胞过程有关，包括增殖、存活、凋亡、转移和化疗耐药。此外，miRNA的改变与特定的临床表型有关，如疾病的进展或复发、转移的发展和手术后的生存。最近的研究探索了miRNAs作为诊断和预后工具以及作为潜在的治疗靶点的用途。在这里，我们讨论miRNA生物学，并提供关于miRNAs在大鼠舌癌发生中作用的关键发现的总结。

项目成果

Heterogeneous nuclear ribonucleopretein K as a new marker of early detection for 4NQO-indced rat tongue carcinogenesis

异质核核糖核蛋白 K 作为 4NQO 诱导的大鼠舌癌早期检测的新标志物

• 发表时间: 2012
• 期刊: 岐阜歯科学会
• 作者: Sakano Y;Tanuma J
• 通讯作者: Tanuma J

hnRNPKと4NQO誘発ラット舌癌の前癌病変との関連

hnRNPK 与 4NQO 诱导的大鼠舌癌癌前病变的关联

• 发表时间: 2011
• 作者: 坂野美栄;永山元彦;江原道子;志佐湍;北野元生;日合弘;田沼順一
• 通讯作者: 田沼順一

原発性骨内扁平上皮癌の一例

原发性骨内鳞状细胞癌1例

• 发表时间: 2012
• 作者: 太田貴久;田沼順一;式守道夫
• 通讯作者: 式守道夫

FGFR4 polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma

• DOI: 10.3892/or_00000692
• 发表时间: 2010-03-01
• 期刊: ONCOLOGY REPORTS
• 影响因子: 4.2
• 作者: Tanuma, Jun-Ichi;Izumo, Toshiyuki;Kitano, Motoo
• 通讯作者: Kitano, Motoo

FGFR4 Gly388Arg polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma

FGFR4 Gly388Arg多态性、TP53突变及其组合是口腔鳞癌的预后因素

• 发表时间: 2010
• 期刊: Oncology Reports 23
• 作者: Tanuma J;Izumo T;Hirano M;Oyazato Y;Hori F;Umemura E;Shisa H;Hiai H;Kitano M.
• 通讯作者: Kitano M.