Study of molecular mechanisms of osteoclast-activation by jaw cyst fluids.

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Jaw cyst and jaw benign tumor grow within a jawbone, resorbing surrounding jawbone. We studied how the osteoclast formation was activated which absorbs a bone how being activated in the process. As a result, it became clear that the cytokine, expressed by those lesions, induced promotes the osteoclast activating factor of the stromal fibroblasts. This pathway was suggested to be one of the mechanisms of the jawbone resorption and lesion-growth into the bone.