The evaluation of Bone Morphogenetic Protein-2(BMP-2) with autogenous bone marrow for the jaw defect.

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We investigated the osteogenic potential of a combination graft of autogenous bone marrow and bone morphogenetic protein(=BMP-2) in the rat calvarial defect. The newly formed bone was studied histologically and radiographically and compared with BMP-2 graft. Sixty days after grafting, the combination graft of autogenous bone marrow and BMP-2 showed new bone formation and no resorption of newly formed bone in the defect. The BMP-2 grafted in the defect showed bone formation and formed bone was resorbed at the edge of the defect. Total bone formation of the vombination of autogenous bone marrow and BMP-2 was obviously increased compared with BMP-2 graft. This result suggested that the newly formed vascularization was important event to increase and keep the volume of newly formed bone in the defect.