Development of diagnostic panel of oral cancer cell properties by genetic polymorphisms and expression properties

为了解口腔鳞状细胞癌特性与基因突变的关系，建立口腔鳞癌治疗方案选择的标准，对口腔鳞状细胞癌的基因表达、基因多态性及个体特性进行了分析。这项研究是在Tsurumi大学伦理审查委员会的批准下进行的。所有患者均在研究前获得知情同意。我们进行SNP分析以确定基因多态性，DNA微阵列分析和蛋白质组分析。在所有分析中都没有找到共同的候选者，但多个候选者的组合是有潜力的。

In order to understand the relationship between OSCC properties and gene mutation and to establish a standard for selection of therapy, the variety of gene expression and polymorphism and individual OSCC cell properties was analyzed. This study was conducted with the approval of Tsurumi University ethical review board. Informed consent was obtained from all of patients prior to this study.We performed SNP analysis to determine the gene polymorphism, DNA microarray analysis and proteome analysis. The common candidate in all analysis was not found but there is potential in combinations of plural candidates.