Development of diagnostic panel of oral cancer cell properties by genetic polymorphisms and expression properties

为了了解口腔鳞癌的性质与基因突变的关系，为临床治疗方案的选择提供依据，本研究分析了口腔鳞癌中基因表达和多态性的变化以及个体细胞的性质。本研究是在鹤见大学伦理审查委员会的批准下进行的。所有患者均在知情同意的基础上进行SNP分析、基因芯片分析和蛋白质组分析。在所有的分析中没有找到共同的候选人，但有可能在多个候选人的组合。

In order to understand the relationship between OSCC properties and gene mutation and to establish a standard for selection of therapy, the variety of gene expression and polymorphism and individual OSCC cell properties was analyzed. This study was conducted with the approval of Tsurumi University ethical review board. Informed consent was obtained from all of patients prior to this study.We performed SNP analysis to determine the gene polymorphism, DNA microarray analysis and proteome analysis. The common candidate in all analysis was not found but there is potential in combinations of plural candidates.