Cardiovascular protective effect of sedation against invasive stress caused by dental care

在培养的大鼠嗜铬细胞瘤细胞(PC12)中，用细胞膜电压敏感型荧光染料测量膜电位。静脉注射咪达唑仑后，未达到检测到细胞膜ATP敏感性钾通道活性的明显变化。进一步制作大鼠慢性疼痛动物模型之一的脊髓神经结扎损伤模型(SNL模型)，分离提取肾上腺嗜铬细胞。然而，这并没有得到足够可测量的细胞。

In cultured rat pheochromocytoma cells(PC12), membrane potential was measured using the cell membrane voltage-sensitive fluorescent dye. Midazolam intravenous anesthetic, did not reach to detect a significant change in activity of the cell membrane ATP-sensitive potassium channels. Furthermore, spinal nerves ligation injury model(SNL model) that was one of the chronic animal pain models with a rat was made, and the adrenal chromaffin cell was isolated and extracted. However, that failed to get a measurable cell enough.