Cardiovascular protective effect of sedation against invasive stress caused by dental care

镇静对牙科护理引起的侵入性应激的心血管保护作用

• 批准号: 21592576
• 负责人: EGUCHI Satoru
• 金额: $ 2.58万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592576/
• 关键词: 精神鎮静法; イオンチャネル

In cultured rat pheochromocytoma cells(PC12), membrane potential was measured using the cell membrane voltage-sensitive fluorescent dye. Midazolam intravenous anesthetic, did not reach to detect a significant change in activity of the cell membrane ATP-sensitive potassium channels. Furthermore, spinal nerves ligation injury model(SNL model) that was one of the chronic animal pain models with a rat was made, and the adrenal chromaffin cell was isolated and extracted. However, that failed to get a measurable cell enough.

在培养的大鼠嗜铬细胞瘤细胞(PC12)中，用细胞膜电压敏感型荧光染料测量膜电位。静脉注射咪达唑仑后，未达到检测到细胞膜ATP敏感性钾通道活性的明显变化。进一步制作大鼠慢性疼痛动物模型之一的脊髓神经结扎损伤模型(SNL模型)，分离提取肾上腺嗜铬细胞。然而，这并没有得到足够可测量的细胞。