Molecular biological study on the mechanism of alveolar bone metabolism through the toll-like receptor 5
Molecular biological study on the mechanism of alveolar bone metabolism through the toll-like receptor 5
批准号:
21592639
负责人:
NAKAMURA Kimiya
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Flagellin, the ligand of Toll like receptor 5, markedly increased the expression of MCP-1 which is one of the CC chemokine, in a dose-dependent manner on osteoblastic MC3T3-E1 cells. In addition, flagellin was significantly suppressed the OPG mRNA expression. Furthermore, anti-MCP-1 antibody was further down-regulated the flagellin-suppressed OPG mRNA expression. These results indicate that osteoblasts are involved in host defense as well as bone metabolism.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
骨芽細胞様MC3T3-E1細胞におけるTLR5リガンドによるMCP-1の発現誘導
TLR5 配体在成骨细胞样 MC3T3-E1 细胞中诱导 MCP-1 表达
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Matsumura Y, Mitani A, Suga T, Kamiya Y, Kikuchi T, Tanaka S, Aino M, Noguchi T, 中村公也,竹原順次,三宅亮,兼平孝]
通讯作者:
中村公也,竹原順次,三宅亮,兼平孝
Flagellin induces MCP-1 in mouse osteoblastic cells
鞭毛蛋白在小鼠成骨细胞中诱导 MCP-1
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kimiya Nakamura, Yoshiaki Deyama, Yoshitaka Yoshimura, Kuniaki Suzuki]
通讯作者:
Kuniaki Suzuki
Toll like receptor 5 ligand induces monocyte chemoattractant protein-1 in mouse osteoblastic cells
Toll样受体5配体诱导小鼠成骨细胞中的单核细胞趋化蛋白-1
DOI:
10.2220/biomedres.33.39
发表时间:
2012
期刊:
Biomedical Research
影响因子:
--
作者:
[Nakamura K, Deyama Y, Yoshimura Y, Suzuki K, Morita M]
通讯作者:
Morita M
Relation between progress of periodontal disease and toll-like receptor ligand
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批准号:19592400
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.33万
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财政年份:2007
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负责人:NAKAMURA Kimiya
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依托单位:
海外基金