The trial of building a nursing assessment for detecting chronic side effects in early stages on radiotherapy.

建立护理评估以检测放疗早期慢性副作用的试验。

• 批准号: 21592676
• 负责人: SEKIMATA Akiko
• 金额: $ 3万
• 依托单位: Yamagata University (2011)Tohoku University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592676/
• 关键词: 放射線治療; DNA修復; 乳がん; 看護アセスメント; DNA損傷修復; DNA損傷修復因子

The screening for detecting genes which involved in breast cancer development revealed 25 related ones. The five of them were unknown as DNA repair factors. Also, we characterized a novel repair gene, MDT1, which we isolated previously, and the experiment showed that MDT1 has a role for the protein metabolism.

对与乳腺癌发生有关的基因进行筛选，发现了25个相关基因。这5个基因是否为DNA修复因子尚不清楚。此外，我们还鉴定了我们先前分离到的一个新的修复基因MDT1，实验表明MDT1对蛋白质代谢具有作用。

项目成果

O-Mannosylation is required for the solubilization of heterologously espressed human beta-amyloid precursor protein in Saccharomyces cerevisiae

O-甘露糖基化对于在酿酒酵母中溶解异源表达的人类 β-淀粉样蛋白前体蛋白是必需的

• 发表时间: 2009
• 期刊: Genes Cells
• 影响因子: 2.1
• 作者: Murakami-Sekimata A;Sato K;Sato K;Takashima A;Nakano A
• 通讯作者: Nakano A

The Saccharomyces cerevisia RAD9, RAD17 and RAD24 genes are required for suppression of mutagenic post-replicative repair during chronic DNA damage

酿酒酵母 RAD9、RAD17 和 RAD24 基因是抑制慢性 DNA 损伤期间诱变复制后修复所必需的

• 发表时间: 2010
• 期刊: DNA Repair (Amst)
• 作者: Murakami-Sekimata A;Huang D;Piening BD;Bangur C;Paulovich AG
• 通讯作者: Paulovich AG

O-mannnosylation is required for the solubilization of heterologously expressed human beta-amyloid precursor protein in Saccharomyces cerevisiae.

O-甘露糖基化是啤酒糖酵母中异源表达的人 β-淀粉样前体蛋白溶解所必需的。

• 发表时间: 2009
• 期刊: Genes to Cells 14
• 作者: Murakami-sekimata A.;Sato K.;Sato K.;Takashima A.;Nakano A.
• 通讯作者: Nakano A.

The Saccharomyces cerevisiae RAD9 gene is required for suppression of mutagenic translesion synthesis during chronic DNA damage.

酿酒酵母 RAD9 基因是抑制慢性 DNA 损伤期间诱变跨损伤合成所必需的。

• 发表时间: 2010
• 作者: Pining B. D.;Huang D.;Murakami-Sekimata A.;Bangur C.;Paulovich AG.
• 通讯作者: Paulovich AG.

A Cross-Species pproch for the Discovery of Genetic Interactions in the DNA Damage Response.

发现 DNA 损伤反应中遗传相互作用的跨物种方法。

• 发表时间: 2010
• 作者: Pining B. D.;Huang D.;Hsu HM.;Wang S.;Murakami-Sekimata A.;Wang P.;Paulovich AG
• 通讯作者: Paulovich AG