Elucidation of the mechanism underlying the suppression of the development of analgesic tolerance to morphine under chronic pain

阐明抑制慢性疼痛下吗啡镇痛耐受发展的机制

• 批准号: 21600012
• 负责人: TAN-NO Koichi
• 金额: $ 3.08万
• 依托单位: Tohoku Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21600012/
• 关键词: モルヒネ; 鎮痛耐性; 身体的依存; 慢性疼痛; 一酸化窒素; ホルマリン試験; マウス; 炎症性疼痛; NMDA受容体; AMPA受容体; L型カルシウムチャネル; DNAマイクロアレイ解析; NOS1AP

This study examined the mechanism underlying suppression of analgesic tolerance to morphine under chronic pain condition. Chronic pain was induced by intraplantar injection of 1% formalin, which significantly suppressed the development of analgesic tolerance to morphine. The formalin-induced suppression of analgesic tolerance to morphine was significantly reversed by L-arginine, a precursor of nitric oxide, but not by D-arginine. These results suggest that suppression of analgesic tolerance to morphine under formalin-induced pain may be mediated through the inhibition of nitric oxide production.

本研究旨在探讨慢性疼痛条件下吗啡镇痛耐受抑制的机制。足底注射1%福尔马林诱导慢性疼痛，显著抑制吗啡镇痛耐受的形成。福尔马林诱导的吗啡镇痛耐受的抑制被一氧化氮的前体L-精氨酸显著逆转，但不被D-精氨酸逆转。这些结果表明，抑制镇痛耐受吗啡下福尔马林诱导的疼痛可能是通过抑制一氧化氮的产生。

项目成果

Phenylmethanesulfonyl fluoride, a serine protease inhibitor, suppresses naloxone-precipitated withdrawal jumping in morphine-dependent mice

• DOI: 10.1016/j.npep.2012.11.002
• 发表时间: 2013-06-01
• 期刊: NEUROPEPTIDES
• 影响因子: 2.9
• 作者: Nemoto, Wataru;Sato, Tasuku;Tan-No, Koichi
• 通讯作者: Tan-No, Koichi

脊髄疼痛伝達機構におけるアンジオテンシンII の役割について

血管紧张素II在脊髓疼痛传递机制中的作用

• 发表时间: 2013
• 作者: S. Katsuyama;H. Mizoguchi;T. Komatsu;C. Sakurada;M. Tsuzuki;S. Sakurada;T. Sakurada;Yoshimura M;Koichi Tan-No;仙波恵美子;八木淳一;鈴木雅美;根本亙,中川西修,八百板富紀枝,三浦圭裕,長谷川大地,大友光平,大堀彩,岡本駿,只野武,丹野孝一
• 通讯作者: 根本亙,中川西修,八百板富紀枝,三浦圭裕,長谷川大地,大友光平,大堀彩,岡本駿,只野武,丹野孝一

モルヒネ鎮痛耐性軽減薬の探索研究-慢性疼痛患者のQOL向上を目指して-

降低吗啡镇痛耐受性药物的探索性研究 - 旨在改善慢性疼痛患者的生活质量 -

• 发表时间: 2009
• 作者: Yokoyama T;Minami K;Sudo Y;Horishita T;Ogata J;Seo M;Uezono Y.;丹野孝一
• 通讯作者: 丹野孝一

Suppressive effects by cysteine protease inhibitors on naloxone-precipitated withdrawal jumping in morphine-dependent mice

半胱氨酸蛋白酶抑制剂对吗啡依赖小鼠纳洛酮诱发的戒断跳跃的抑制作用

• DOI: 10.1016/j.npep.2010.02.001
• 发表时间: 2010
• 期刊: Neuropeptides
• 影响因子: 2.9
• 作者: Tan-No K.;Sato T.;Shimoda M.;Nakagawasai O.;Niijima F.;KawamuraS.;Furuta S.;Sato T.;Satoh S.;Silberring J.;Terenius L.;Takeshi Tadano
• 通讯作者: Takeshi Tadano

Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolrrance to morphine

p53 肿瘤抑制蛋白参与吗啡抗伤害耐受的发展

• 发表时间: 2011
• 作者: Yanagisawa Y;Furue H;Kawamata T;Namiki A;Iwamoto Y;Yoshimura M;Koichi Tan-No
• 通讯作者: Koichi Tan-No