Interpretation for diffusion weighted MRI image by computer simulation with brain blood vessel model

我们通过计算机模拟揭示脑血容量（CBV）与扩散加权磁共振图像之间的关系。由典型的单次重聚焦脉冲梯度自旋回波序列计算的表观扩散系数（ADC）由于血管网络的磁化率尤其是脑内小血管数量的增加而被低估。结果表明，采用二次重聚焦自旋回波序列可以降低ADC的影响。

We performed computer simulation to reveal a relation between cerebral blood volume(CBV) and diffusion weighted magnetic resonance image. Apparent diffusion coefficient(ADC) calculated from typical single refocused pulsed-gradient spin-echo sequence was underestimated by magnetic susceptibility of vascular networks especially from increase number of small vessels in brain. We confirm the influence of ADC can be reduced by using twice-refocused spin-echo sequence.