Effects of habitual exercise and combination of two polymorphisms on arterial stiffness

随着年龄的增长，动脉硬度的增加与几种病理状态有关，包括高血压、动脉粥样硬化、充血性心力衰竭、中风和主动脉根部反流。因此，动脉硬化增加可能是全因死亡率和心血管疾病发展的独立危险因素。习惯性运动可以防止和/或逆转随着年龄增长而增加的动脉硬化。另一方面，动脉硬化的增加与遗传因素有关。在目前的研究中，我们研究了两种多态性组合对动脉硬化增加风险的影响。我们发现雌激素受体α - 401t /C和血管紧张素转换酶I/D的TT和II基因型的组合分别显著增加了中老年人动脉僵硬增加的风险。

An increase in arterial stiffness with advancing age is associated with several pathological states, including hypertension, atherosclerosis, congestive heart failure, stroke, and aortic root regurgitation. Therefore, increased arterial stiffness may be an independent risk factor for all-cause mortality and the development of cardiovascular disorders. Habitual exercise prevents and/or reverses the increases in arterial stiffness with advancing age. On the other hand, the increase in arterial stiffness is associated with genetic factors. In the present study, we examined the effects of the combination of two polymorphisms on the risk for increase in arterial stiffness. We revealed that a combination of TT and II genotypes in estrogen receptor alpha-401T/C and angiotensin-converting enzyme I/D, respectively, remarkably elevated the risk for increase in arterial stiffness in middle-aged and elderly humans.