Does pentraxin 3 participate in the mechanism underlying habitual aerobic exercise-induced increase in arterial distensibility?

pentraxin 3 是否参与了习惯性有氧运动引起的动脉扩张性增加的机制？

• 批准号: 21300234
• 负责人: MAEDA Seiji
• 金额: $ 11.23万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300234/
• 关键词: 有酸素性運動; 動脈伸展性; ペントラキシン3; 抗炎症作用; 加齢; 肥満; 心血管疾患; 心血管保護作用; 閉経後中高齢女性; 運動トレーニング; 大動脈; 持久鍛錬者; 生活習慣

Aging and/or obesity induce the decrease in arterial distensibility. Reduction in arterial distensibility is believed to contribute to the pathophysiology of cardiovascular disease and has been identified as a powerful and independent risk factor for cardiovascular disease. On the other hand, habitual aerobic exercise results in a significant increase in arterial distensibility. However, it is unclear the mechanism underlying habitual aerobic exercise-induced enhancement of arterial distensibility. The present study was to investigate whether pentraxin 3 (PTX3), anti-inflammatory protein, is involved in the mechanism underlying the increase in arterial distensibility with aerobic exercise training. We suggest that PTX3 may be an important mechanism underlying the beneficial effect of aerobic exercise training on arterial distensibility.

衰老和/或肥胖诱导动脉扩张性降低。动脉扩张性的降低被认为有助于心血管疾病的病理生理学，并且已被确定为心血管疾病的强大且独立的风险因素。另一方面，习惯性有氧运动会导致动脉扩张性显著增加。然而，习惯性有氧运动引起动脉扩张性增强的机制尚不清楚。本研究旨在探讨抗炎蛋白正五聚蛋白3（pentraxin 3，PTX 3）是否参与有氧运动训练增加动脉扩张性的机制。我们认为PTX 3可能是有氧运动训练对动脉扩张性有益作用的重要机制。

项目成果

Plasma Pentraxin 3 Concentration Increases in Endurance-Trained Men

• DOI: 10.1249/mss.0b013e3181e84bce
• 发表时间: 2011-01-01
• 期刊: MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
• 作者: Miyaki, Asako;Maeda, Seiji;Ajisaka, Ryuichi
• 通讯作者: Ajisaka, Ryuichi

有酸素性運動および抵抗性運動が動脈スティフネスと血中PTX3濃度に与える影

有氧运动和抗阻运动对动脉僵硬度和血液PTX3浓度的影响

• 发表时间: 2009
• 作者: 三瀬陽;長谷川裕晃;松内一雄;宮木亜沙子
• 通讯作者: 宮木亜沙子

中高齢女性における習慣的な有酸素性運動が血中PTX3濃度に及ぼす影響

习惯性有氧运动对中老年女性血PTX3浓度的影响

• 发表时间: 2011
• 作者: 高木紀明;王碩玉;三浦直樹;姜銀来;宮木亜沙子
• 通讯作者: 宮木亜沙子

Habitual aerobic exercise increases plasma pentraxin 3 levels in middle-aged and elderly women

• DOI: 10.1139/h2012-069
• 发表时间: 2012-10-01
• 期刊: APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
• 影响因子: 3.4
• 作者: Miyaki, Asako;Maeda, Seiji;Ajisaka, Ryuichi
• 通讯作者: Ajisaka, Ryuichi

中高齢女性における習慣的な有酸素性運動が血中PTX3濃度に及ぼす影

习惯性有氧运动对中老年女性血PTX3浓度的影响

• 发表时间: 2011
• 作者: 柿山哲治;佐久本稔;工藤和俊;宮木亜沙子
• 通讯作者: 宮木亜沙子