Central mechanisms of circadian entrainment via oral functions

许多动物都有预测周期性食物供应的能力。在这项研究中，我们研究了生物钟缺陷小鼠的食物预期活动。一些内在昼夜节律有细微差异的KO小鼠对不同时期的摄食表现出有限的干扰；而其他分子钟缺陷小鼠则没有。这些结果表明，标准分子钟可能不会驱动食物预期行为活动，但可能作为昼夜节律方式控制它。

Many animals have an ability to anticipate periodic food availability. In this study, we have examined the food anticipatory activity in circadian clock deficient mice. Some KO mice which have slightly differences in intrinsic circadian period show limited entrainment to various period of feeding ; the other molecular clock deficient mice do not. These results suggest that the canonical molecular clock may not drive food anticipatory behavioral activity, but may control it as a circadian manner.