Roles of Msx2 in osteoblast proliferation, differentiation and activation for bone remodeling.

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To date, there have been no clear reports that Msx2 take part in the mechanism of osteoblast differentiation, which is responsible for the bone remodeling and regeneration in orthodontic treatments. The purpose of the present study, therefore, was to investigate the roles of Msx2 in osteoblast differentiation and bone formation with mouse Embryonic Stem cells. ES cells which transfected with Msx2 were cocultured with feeder cells, and alkaline phosphatase activity and mRNA levels of osteoblastic phenotype were determined for cell differentiation. The value of bone nodules was also determined for mineralization. As a result, it was suggested that Msx2 play a key role in controlling osteoblast differentiation.