Correlation between fibrinogen and IL-6 in progression of periodontitis-in vivo analyses-

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Fibrinogen is an acute-phase protein synthesized both by hepatic and nonhepatic cells in response to proinflammatory cytokines such as IL-6. We have demonstrated that the -1420G/A, -854G/A and -148C/T polymorphisms in the β-fibrinogen promoter region are determinants of IL6-induced activity, and could be functional polymorphisms. While, it is reported that there is a strong linkage disequilibrium in some races among the 4 common polymorphisms (-1420G/A, -993C/T, -455G/A and -148C/T).In the study, we performed the gene polymorphism analysis in the β-fibrinogen promoter region. The results indicated that the presence of the linkage disequilibrium among the 4 common polymorphisms in Japanese population.