Study of IGF-I effect on anti-aging for the jawbone

IGF-I抗颌骨衰老作用的研究

• 批准号: 21792140
• 负责人: KOJIMA Ikuho
• 金额: $ 2.58万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792140/
• 关键词: IGF-I; 骨; アンチエイジング; IGF-1

The results of IGF-I administration for normal rat were as follows. 1)Bone mineral density (BMD)analyzed by X-ray photograph increased in lower area of mandibular condyle. 2)On measurement about bone matrix ratio (BMR), BMR was greater in lower part of mandibular condyle (Cd)vertically divided into three parts, and was greater in central part of laterally divided Cd. 3)On measurement about osteoblast, the number of osteoblasts was greater in central and lower parts of vertically divided Cd, and in inside and outside parts of laterally divided Cd. 4)On measurement about osteoclast, the number of osteoclasts has no change in any parts of Cd. 5)These changes during IGF-I administration disappeared after IGF-I administration ended.

对正常大鼠施用IGF-I的结果如下。 1)X线照片分析下颌骨髁下部区域骨密度(BMD)增加。 2)骨基质比(BMR)测定中，下颌骨髁突(Cd)垂直分为三部分的下部BMR较大，横向分为Cd的中央部分较大。 3)对成骨细胞的测量，垂直分割的Cd的中央和下部以及横向分割的Cd的内侧和外侧部分的成骨细胞数量较多。 4)破骨细胞测定中，Cd各部位破骨细胞数量均无变化。 5)IGF-I施用期间的这些变化在IGF-I施用结束后消失。

项目成果

Morphological and histopathological changes in orofacial structures of experimentally developed acromegaly-like rats: an overview.

• DOI: 10.1155/2012/254367
• 发表时间: 2012
• 期刊: International journal of endocrinology
• 影响因子: 2.8
• 作者: Iikubo M;Kojima I;Sakamoto M;Kobayashi A;Ikeda H;Sasano T
• 通讯作者: Sasano T

Mechanisms of edematous changes in masseter muscle evoked by muscle pain

肌痛引起咬肌水肿变化的机制

• 发表时间: 2011
• 作者: Iikubo M;et al
• 通讯作者: et al

Morphological study on the dental arch in experimentally developed acromegaly-like rats

实验性肢端肥大症样大鼠牙弓的形态学研究

• 发表时间: 2010
• 作者: Ikuho Kojima;et. al.
• 通讯作者: et. al.