Establishment of Rat Periodontitis Model With Periodontal Pocket Formation and Elucidation of the Junctional Epithelium Destruction Mechanism

牙周袋形成大鼠牙周炎模型的建立及结合上皮破坏机制的阐明

• 批准号: 21792125
• 负责人: YOSHINAGA Yasunori
• 金额: $ 2.66万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792125/
• 关键词: 歯周ポケット形成; LPS; 歯槽骨吸収; 免疫感作; 歯周炎モデル

LPS was introduced daily into the palatal gingival sulcus of first molars in LPS-sensitized (sensitized group) or non-sentized rats (non-sensitized group). There was a significantly increase in apical migration of JE, pocket formation, bone resorption, the number of RANKL-bearing cells in the sensitized group than in the non-sensitized group. We could clearly demonstrate pocket formation and bone resorption in LPS-sensitized rats on day 30.

LPS致敏组（致敏组）和非致敏组（非致敏组）大鼠第一磨牙腭龈沟每日注射LPS。与未致敏组相比，致敏组乙脑的根尖迁移、口袋形成、骨吸收、携带rankl的细胞数量显著增加。我们可以清楚地看到，lps致敏大鼠在第30天的口袋形成和骨吸收。

项目成果

An experimental model of periodontitis in LPS-Immunized rat.

LPS免疫大鼠牙周炎实验模型。

• 作者: Yoshinaga Y;Kuramoto A;Kaneko T;Ukai T;Shiraishi C;Yoshinaga M;Sato T;Nagano F;Hara Y.
• 通讯作者: Hara Y.

ホームページ等。

主页等

歯周炎発症メカニズム研究-実験的歯周炎モデルの確立-

牙周炎发病机制研究-实验性牙周炎模型的建立-

• 发表时间: 2009
• 作者: Kojima I;Iikubo M;Sakamoto M;Sasano T;吉永泰周
• 通讯作者: 吉永泰周